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    TYMS thymidylate synthetase [ Homo sapiens (human) ]

    Gene ID: 7298, updated on 15-Oct-2017
    Official Symbol
    TYMSprovided by HGNC
    Official Full Name
    thymidylate synthetaseprovided by HGNC
    Primary source
    HGNC:HGNC:12441
    See related
    Ensembl:ENSG00000176890 MIM:188350; Vega:OTTHUMG00000131473
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TS; TMS; HST422
    Summary
    Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
    Orthologs
    Location:
    18p11.32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 18 NC_000018.10 (657604..673499)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (657590..673499)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SK small nuclear pseudogene 146 Neighboring gene clusterin like 1 Neighboring gene uncharacterized LOC105371952 Neighboring gene TYMS opposite strand Neighboring gene enolase superfamily member 1 Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase Neighboring gene RNA, U1 small nuclear 109, pseudogene Neighboring gene bolA family member 2 pseudogene 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC88736

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cofactor binding IEA
    Inferred from Electronic Annotation
    more info
     
    drug binding IEA
    Inferred from Electronic Annotation
    more info
     
    folic acid binding IC
    Inferred by Curator
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thymidylate synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thymidylate synthase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    translation repressor activity, nucleic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA biosynthetic process IC
    Inferred by Curator
    more info
    PubMed 
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    cell growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    dTMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dTTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    dUMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    developmental growth IEA
    Inferred from Electronic Annotation
    more info
     
    immortalization of host cell by virus IEA
    Inferred from Electronic Annotation
    more info
     
    intestinal epithelial cell maturation IEA
    Inferred from Electronic Annotation
    more info
     
    liver regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleobase-containing small molecule interconversion TAS
    Traceable Author Statement
    more info
     
    regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    response to cytokine IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to folic acid IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    response to organophosphorus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    response to vitamin A IEA
    Inferred from Electronic Annotation
    more info
     
    tetrahydrofolate interconversion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    uracil metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    thymidylate synthase
    Names
    TSase
    NP_001062.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028255.1 RefSeqGene

      Range
      5001..20896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_783

    mRNA and Protein(s)

    1. NM_001071.2NP_001062.1  thymidylate synthase isoform 1

      See identical proteins and their annotated locations for NP_001062.1

      Status: REVIEWED

      Source sequence(s)
      AP001178, BC083512, X02308
      Consensus CDS
      CCDS11821.1
      UniProtKB/Swiss-Prot
      P04818
      UniProtKB/TrEMBL
      Q53Y97
      Related
      ENSP00000315644.10, OTTHUMP00000162195, ENST00000323274.14, OTTHUMT00000254316
      Conserved Domains (1) summary
      pfam00303
      Location:32313
      Thymidylat_synt; Thymidylate synthase
    2. NM_001354867.1NP_001341796.1  thymidylate synthase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB077208, AK223372, BC083512, HY016886, HY269620
      Conserved Domains (1) summary
      cl19097
      Location:27279
      TS_Pyrimidine_HMase; Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the ...
    3. NM_001354868.1NP_001341797.1  thymidylate synthase isoform 3

      Status: REVIEWED

      Source sequence(s)
      AB077207, AK223372, BC083512, HY016886, HY269620
      Conserved Domains (1) summary
      pfam00303
      Location:32230
      Thymidylat_synt; Thymidylate synthase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p7 Primary Assembly

      Range
      657604..673499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018929.2 Alternate CHM1_1.1

      Range
      656968..672692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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