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    Ero1l ERO1-like (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 50527, updated on 26-Nov-2016
    Official Symbol
    Ero1lprovided by MGI
    Official Full Name
    ERO1-like (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1354385
    See related
    Ensembl:ENSMUSG00000021831
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ero1a; ERO1-L
    Summary
    This gene encodes a member of the endoplasmic reticulum oxidoreductin family. The encoded protein is localized to the endoplasmic reticulum and promotes the formation of disulfide bonds by oxidizing protein disulfide isomerase. This gene may play a role in endoplasmic reticulum stress-induced apoptosis and the cellular response to hypoxia. [provided by RefSeq, Feb 2011]
    Orthologs
    Location:
    14; 14 C1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (45283087..45318572, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (45903996..45938202, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 16 Neighboring gene tubulin, beta 6 pseudogene Neighboring gene G protein-coupled receptor 137C Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 6 Neighboring gene serine/threonine/tyrosine interaction protein Neighboring gene glucosamine-phosphate N-acetyltransferase 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein disulfide oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    4-hydroxyproline metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell redox homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular protein modification process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chaperone mediated protein folding requiring cofactor ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum unfolded protein response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein folding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein folding in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein maturation by protein folding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    ERO1-like protein alpha
    Names
    ERO1-L-alpha
    endoplasmic oxidoreductin-1-like protein
    endoplasmic reticulum oxidation 1
    endoplasmic reticulum oxidoreductase alpha
    endoplasmic reticulum oxidoreductin-1-like protein
    oxidoreductin-1-L-alpha
    NP_056589.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015774.3NP_056589.1  ERO1-like protein alpha precursor

      See identical proteins and their annotated locations for NP_056589.1

      Status: REVIEWED

      Source sequence(s)
      AC154575, AK009667, AK142595, BP753202, CJ215857
      Consensus CDS
      CCDS36893.1
      UniProtKB/Swiss-Prot
      Q8R180
      UniProtKB/TrEMBL
      Q4FK57
      Related
      ENSMUSP00000022378, ENSMUST00000022378
      Conserved Domains (1) summary
      pfam04137
      Location:60451
      ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      45283087..45318572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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