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    SRRT serrate, RNA effector molecule [ Homo sapiens (human) ]

    Gene ID: 51593, updated on 6-Jun-2017
    Official Symbol
    SRRTprovided by HGNC
    Official Full Name
    serrate, RNA effector moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:24101
    See related
    Ensembl:ENSG00000087087 MIM:614469; Vega:OTTHUMG00000157031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARS2; ASR2; serrate
    Orthologs
    Location:
    7q22.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (100874971..100888664)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100472701..100486285)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 9 Neighboring gene microRNA 6875 Neighboring gene thyroid hormone receptor interactor 6 Neighboring gene UFM1 specific peptidase 1 (inactive) Neighboring gene acetylcholinesterase (Cartwright blood group)

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association analysis identifies multiple loci related to resting heart rate.
    NHGRI GWA Catalog
    Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of serrate RNA effector molecule homolog (SRRT) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • RNA polymerase II transcribes snRNA genes, organism-specific biosystem (from REACTOME)
      RNA polymerase II transcribes snRNA genes, organism-specific biosystemSmall nuclear RNAs (snRNAs) play key roles in splicing and some of them, specifically the U1 and U2 snRNAs, are encoded by multicopy snRNA gene clusters containing tandem arrays of genes, about 30 in...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC126427

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    neuronal stem cell population maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    primary miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to arsenic-containing substance NAS
    Non-traceable Author Statement
    more info
    PubMed 
    snRNA transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    serrate RNA effector molecule homolog
    Names
    arsenate resistance protein 2
    arsenate resistance protein ARS2
    arsenite resistance protein
    arsenite-resistance protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128852.1NP_001122324.1  serrate RNA effector molecule homolog isoform c

      See identical proteins and their annotated locations for NP_001122324.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the end of a 5' exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
      Source sequence(s)
      AC011895, AL096723, DA611314
      Consensus CDS
      CCDS47666.1
      UniProtKB/Swiss-Prot
      Q9BXP5
      Related
      ENSP00000481173.1, OTTHUMP00000276011, ENST00000614484.4, OTTHUMT00000347166
      Conserved Domains (2) summary
      pfam04959
      Location:645850
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153262
      DUF3546; Domain of unknown function (DUF3546)
    2. NM_001128853.1NP_001122325.1  serrate RNA effector molecule homolog isoform d

      See identical proteins and their annotated locations for NP_001122325.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the end of a 3' exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is 4 aa shorter compared to isoform a.
      Source sequence(s)
      AF248955, BC109117, DA611314
      Consensus CDS
      CCDS47665.1
      UniProtKB/Swiss-Prot
      Q9BXP5
      Related
      ENSP00000478341.1, OTTHUMP00000276010, ENST00000618262.4, OTTHUMT00000347165
      Conserved Domains (2) summary
      pfam04959
      Location:646847
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153262
      DUF3546; Domain of unknown function (DUF3546)
    3. NM_001128854.1NP_001122326.1  serrate RNA effector molecule homolog isoform e

      See identical proteins and their annotated locations for NP_001122326.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses alternate in-frame splice junctions at the ends of a 5' and 3' exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is 5 aa shorter compared to isoform a.
      Source sequence(s)
      AF248955, BC109117, DA611314
      Consensus CDS
      CCDS47667.1
      UniProtKB/Swiss-Prot
      Q9BXP5
      Related
      ENSP00000483556.1, OTTHUMP00000276013, ENST00000618411.4, OTTHUMT00000347167
      Conserved Domains (2) summary
      pfam04959
      Location:645846
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153262
      DUF3546; Domain of unknown function (DUF3546)
    4. NM_015908.5NP_056992.4  serrate RNA effector molecule homolog isoform a

      See identical proteins and their annotated locations for NP_056992.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC011895, AF248955, BC109116, DA611314
      Consensus CDS
      CCDS34709.1
      UniProtKB/Swiss-Prot
      Q9BXP5
      Related
      ENSP00000480421.1, OTTHUMP00000276014, ENST00000611405.4, OTTHUMT00000347168
      Conserved Domains (2) summary
      pfam04959
      Location:646851
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153262
      DUF3546; Domain of unknown function (DUF3546)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      100874971..100888664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012290.1XP_016867779.1  serrate RNA effector molecule homolog isoform X5

    2. XM_017012291.1XP_016867780.1  serrate RNA effector molecule homolog isoform X6

    3. XM_005250405.2XP_005250462.1  serrate RNA effector molecule homolog isoform X1

      Conserved Domains (2) summary
      pfam04959
      Location:653858
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:160269
      DUF3546; Domain of unknown function (DUF3546)
    4. XM_005250407.2XP_005250464.1  serrate RNA effector molecule homolog isoform X3

      Conserved Domains (2) summary
      pfam04959
      Location:653854
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:160269
      DUF3546; Domain of unknown function (DUF3546)
    5. XM_005250406.2XP_005250463.1  serrate RNA effector molecule homolog isoform X2

      Conserved Domains (2) summary
      pfam04959
      Location:652857
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:160269
      DUF3546; Domain of unknown function (DUF3546)
    6. XM_005250408.2XP_005250465.1  serrate RNA effector molecule homolog isoform X4

      Conserved Domains (2) summary
      pfam04959
      Location:652853
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:160269
      DUF3546; Domain of unknown function (DUF3546)

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      100403311..100416895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182800.2: Suppressed sequence

      Description
      NM_182800.2: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript, and it is a nonsense-mediated mRNA decay (NMD) candidate.
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