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    Vdac1 voltage-dependent anion channel 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83529, updated on 8-Oct-2017
    Official Symbol
    Vdac1provided by RGD
    Official Full Name
    voltage-dependent anion channel 1provided by RGD
    Primary source
    RGD:621575
    See related
    Ensembl:ENSRNOG00000006375
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    large diameter (2.5-3 nm) channel, permeable to ions and small molecules; molecular component of Ca2+ transport across the mitochondrial membranes [RGD, Jun 2006]
    Orthologs
    Location:
    10q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (37724915..37752827)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (37498352..37525819)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene S-phase kinase-associated protein 1 Neighboring gene transcription factor 7 Neighboring gene similar to HTGN29 protein; keratinocytes associated transmembrane protein 2 Neighboring gene uncharacterized LOC102548512

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Mitophagy, organism-specific biosystem (from REACTOME)
      Mitophagy, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
    • Pink/Parkin Mediated Mitophagy, organism-specific biosystem (from REACTOME)
      Pink/Parkin Mediated Mitophagy, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    anion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium channel activity TAS
    Traceable Author Statement
    more info
     
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ion channel binding IEA
    Inferred from Electronic Annotation
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    porin activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    voltage-gated anion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    voltage-gated anion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    anion transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    learning IEA
    Inferred from Electronic Annotation
    more info
     
    learning ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial calcium ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    negative regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron-neuron synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    neuron-neuron synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of autophagy of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    pore complex IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    voltage-dependent anion-selective channel protein 1
    Names
    VDAC-1
    outer mitochondrial membrane protein porin 1
    rVDAC1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031353.1NP_112643.1  voltage-dependent anion-selective channel protein 1

      See identical proteins and their annotated locations for NP_112643.1

      Status: PROVISIONAL

      Source sequence(s)
      AB039662
      UniProtKB/Swiss-Prot
      Q9Z2L0
      Related
      ENSRNOP00000008477.4, ENSRNOT00000008477.5
      Conserved Domains (1) summary
      cd07306
      Location:4282
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      37724915..37752827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      35886487..35913291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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