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    Frs2 fibroblast growth factor receptor substrate 2 [ Mus musculus (house mouse) ]

    Gene ID: 327826, updated on 8-Oct-2017
    Official Symbol
    Frs2provided by MGI
    Official Full Name
    fibroblast growth factor receptor substrate 2provided by MGI
    Primary source
    MGI:MGI:1100860
    See related
    Ensembl:ENSMUSG00000020170
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SNT1; Frs2alpha; 4732458E18; C330018A15Rik
    Orthologs
    Location:
    10; 10 D2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (117070127..117148474, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (116507183..116585530, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 10 Neighboring gene chaperonin containing Tcp1, subunit 2 (beta) Neighboring gene RIKEN cDNA 4930423D24 gene Neighboring gene predicted gene, 40769 Neighboring gene YEATS domain containing 4 Neighboring gene predicted gene, 31963

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    neurotrophin TRKA receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of MAPK activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterior/posterior axis specification, embryo IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lens fiber cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lens fiber cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    neuroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    optic placode formation involved in camera-type eye formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    organ induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    fibroblast growth factor receptor substrate 2
    Names
    FGFR substrate 2
    FGFR-signaling adaptor SNT
    FRS2-alpha
    SNT-1
    suc1-associated neurotrophic factor target 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177798.3NP_808466.1  fibroblast growth factor receptor substrate 2

      See identical proteins and their annotated locations for NP_808466.1

      Status: PROVISIONAL

      Source sequence(s)
      BC043109
      Consensus CDS
      CCDS24190.1
      UniProtKB/Swiss-Prot
      Q8C180
      Related
      ENSMUSP00000020381.3, ENSMUST00000020381.4
      Conserved Domains (1) summary
      cd01202
      Location:15106
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      117070127..117148474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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