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    DIMT1 DIM1 dimethyladenosine transferase 1 homolog [ Homo sapiens (human) ]

    Gene ID: 27292, updated on 23-May-2018
    Official Symbol
    DIMT1provided by HGNC
    Official Full Name
    DIM1 dimethyladenosine transferase 1 homologprovided by HGNC
    Primary source
    HGNC:HGNC:30217
    See related
    Ensembl:ENSG00000086189 MIM:612499; Vega:OTTHUMG00000131223
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIM1; DIMT1L; HUSSY5; HSA9761
    Summary
    The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 12.5), lymph node (RPKM 11.7) and 25 other tissues See more
    Orthologs
    See DIMT1 in Genome Data Viewer
    Location:
    5q12.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (62387953..62403960, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (61684351..61699728, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378998 Neighboring gene RNA, 7SK small nuclear pseudogene 157 Neighboring gene CREB regulated transcription coactivator 2 pseudogene Neighboring gene kinesin family member 2A Neighboring gene RNA, U6 small nuclear 661, pseudogene Neighboring gene importin 11 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 3

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of DIM1 dimethyladenosine transferase 1 homolog (DIMT1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • rRNA modification in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
      rRNA modification in the nucleus and cytosol, organism-specific biosystemHuman ribosomal RNAs (rRNAs) contain about 200 residues that are enzymatically modified after transcription in the nucleolus (Maden and Khan 1977, Maden 1988, Maden and Hughes 1997, reviewed in Herna...
    • rRNA processing, organism-specific biosystem (from REACTOME)
      rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
    • rRNA processing in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
      rRNA processing in the nucleus and cytosol, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    positive regulation of rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    rRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rRNA methylation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    probable dimethyladenosine transferase
    Names
    18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
    18S rRNA dimethylase
    DIM1 dimethyladenosine transferase 1-like
    S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
    dimethyladenosine transferase
    probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
    probable 18S rRNA dimethylase
    probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
    NP_001335005.1
    NP_001335006.1
    NP_055288.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348076.1NP_001335005.1  probable dimethyladenosine transferase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC016637, BC002841, DC398380
      UniProtKB/Swiss-Prot
      Q9UNQ2
      UniProtKB/TrEMBL
      A0A0C4DGB1
      Related
      ENSP00000421754.1, ENST00000506390.5
      Conserved Domains (1) summary
      cl17173
      Location:24263
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001348077.1NP_001335006.1  probable dimethyladenosine transferase isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC016637
      Conserved Domains (1) summary
      cl17173
      Location:1159
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_014473.3NP_055288.1  probable dimethyladenosine transferase isoform 1

      See identical proteins and their annotated locations for NP_055288.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC016637, AK292723, BQ009563, DC398380
      Consensus CDS
      CCDS3981.1
      UniProtKB/Swiss-Prot
      Q9UNQ2
      UniProtKB/TrEMBL
      A8K9K8
      Related
      ENSP00000199320.4, OTTHUMP00000161884, ENST00000199320.8, OTTHUMT00000253967
      Conserved Domains (1) summary
      PTZ00338
      Location:24312
      PTZ00338; dimethyladenosine transferase-like protein; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

      Range
      62387953..62403960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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