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    Cntnap1 contactin associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84008, updated on 7-May-2017
    Official Symbol
    Cntnap1provided by RGD
    Official Full Name
    contactin associated protein 1provided by RGD
    Primary source
    RGD:70902
    See related
    Ensembl:ENSRNOG00000020277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Caspr
    Summary
    forms a complex with contactin; may mediate communication between glial cells and neurons during development [RGD, Feb 2006]
    Orthologs
    Location:
    10q31
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89087904..89103615)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (88888142..88902111)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene tubulin, gamma 2 Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H3 Neighboring gene C-C motif chemokine receptor 10 Neighboring gene enhancer of zeste 1 polycomb repressive complex 2 subunit Neighboring gene receptor activity modifying protein 2

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    myelination TAS
    Traceable Author Statement
    more info
    PubMed 
    neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process controlling balance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuromuscular process controlling posture ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process controlling posture ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuronal action potential propagation ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal action potential propagation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    paranodal junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    paranodal junction assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    paranodal junction assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    protein localization to paranode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to paranode region of axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    paranode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    paranode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    contactin-associated protein 1
    Names
    caspr1
    neurexin IV
    neurexin-4
    p190
    paranodin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032061.2NP_114450.1  contactin-associated protein 1 precursor

      See identical proteins and their annotated locations for NP_114450.1

      Status: VALIDATED

      Source sequence(s)
      AF000114, BF393814, CB610334, U87224
      UniProtKB/Swiss-Prot
      P97846
      Related
      ENSRNOP00000027505.6, ENSRNOT00000027505.6
      Conserved Domains (7) summary
      smart00294
      Location:13051323
      4.1m; putative band 4.1 homologues' binding motif
      smart00231
      Location:25169
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00282
      Location:10841219
      LamG; Laminin G domain
      cd00057
      Location:37168
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:176331
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:545574
      EGF; EGF-like domain
      cl00085
      Location:585659
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      89087904..89103615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768124.2XP_008766346.1  contactin-associated protein 1 isoform X2

      See identical proteins and their annotated locations for XP_008766346.1

      Conserved Domains (7) summary
      smart00294
      Location:12281246
      4.1m; putative band 4.1 homologues' binding motif
      smart00231
      Location:192
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00282
      Location:10071142
      LamG; Laminin G domain
      cd00057
      Location:191
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:99254
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:468497
      EGF; EGF-like domain
      cl00085
      Location:508582
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    2. XM_008768123.2XP_008766345.1  contactin-associated protein 1 isoform X2

      See identical proteins and their annotated locations for XP_008766345.1

      Conserved Domains (7) summary
      smart00294
      Location:12281246
      4.1m; putative band 4.1 homologues' binding motif
      smart00231
      Location:192
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00282
      Location:10071142
      LamG; Laminin G domain
      cd00057
      Location:191
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:99254
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:468497
      EGF; EGF-like domain
      cl00085
      Location:508582
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    3. XM_008768122.2XP_008766344.1  contactin-associated protein 1 isoform X1

      Conserved Domains (7) summary
      smart00294
      Location:13111329
      4.1m; putative band 4.1 homologues' binding motif
      smart00231
      Location:25175
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00282
      Location:10901225
      LamG; Laminin G domain
      cd00057
      Location:37174
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:182337
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:551580
      EGF; EGF-like domain
      cl00085
      Location:591665
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    4. XM_017597554.1XP_017453043.1  contactin-associated protein 1 isoform X2

      Conserved Domains (7) summary
      smart00294
      Location:12281246
      4.1m; putative band 4.1 homologues' binding motif
      smart00231
      Location:192
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00282
      Location:10071142
      LamG; Laminin G domain
      cd00057
      Location:191
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:99254
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:468497
      EGF; EGF-like domain
      cl00085
      Location:508582
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    5. XM_006247431.3XP_006247493.1  contactin-associated protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006247493.1

      Conserved Domains (7) summary
      smart00294
      Location:12281246
      4.1m; putative band 4.1 homologues' binding motif
      smart00231
      Location:192
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00282
      Location:10071142
      LamG; Laminin G domain
      cd00057
      Location:191
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:99254
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:468497
      EGF; EGF-like domain
      cl00085
      Location:508582
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    6. XM_017597555.1XP_017453044.1  contactin-associated protein 1 isoform X2

      Conserved Domains (7) summary
      smart00294
      Location:12281246
      4.1m; putative band 4.1 homologues' binding motif
      smart00231
      Location:192
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00282
      Location:10071142
      LamG; Laminin G domain
      cd00057
      Location:191
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:99254
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:468497
      EGF; EGF-like domain
      cl00085
      Location:508582
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      84829245..84843011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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