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    FRZB frizzled related protein [ Bos taurus (cattle) ]

    Gene ID: 281170, updated on 3-Apr-2018
    Official Symbol
    FRZBprovided by VGNC
    Official Full Name
    frizzled related proteinprovided by VGNC
    Primary source
    VGNC:VGNC:29124
    See related
    BGD:BT17979; Ensembl:ENSBTAG00000010977
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    Location:
    chromosome: 2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    105 current Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 2 AC_000159.1 (13723772..13761804)

    Chromosome 2 - AC_000159.1Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 19 Neighboring gene NCK associated protein 1 Neighboring gene small nuclear ribonucleoprotein E pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C10 Neighboring gene phosphodiesterase 1A Neighboring gene zinc finger protein 160-like

    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Endochondral Ossification, organism-specific biosystem (from WikiPathways)
      Endochondral Ossification, organism-specific biosystemEndochondral ossification is the process by which the embryonic cartilaginous model of most bones contributes to longitudinal growth and is gradually replaced by bone. During endochondral ossificatio...

    Markers

    Homology

    Clone Names

    • MGC137621

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt-protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cochlea morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    convergent extension involved in organogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hepatocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    neural crest cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    somite development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    secreted frizzled-related protein 3
    Names
    frizzled-related protein 1
    frzB-1
    sFRP-3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174059.2NP_776484.1  secreted frizzled-related protein 3 precursor

      See identical proteins and their annotated locations for NP_776484.1

      Status: PROVISIONAL

      Source sequence(s)
      U24164
      UniProtKB/Swiss-Prot
      Q95117
      Related
      ENSBTAP00000014572.3, ENSBTAT00000014572.3
      Conserved Domains (2) summary
      cd07441
      Location:32157
      CRD_SFRP3; Cysteine-rich domain of the secreted frizzled-related protein 3 (SFRP3, alias FRZB), a Wnt antagonist
      cd03581
      Location:188297
      NTR_Sfrp3_like; NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily; composed of proteins similar to human Sfrp3 and Sfrp4. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse functions ...

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Bos_taurus_UMD_3.1.1 Primary Assembly

    Genomic

    1. AC_000159.1 Reference Bos_taurus_UMD_3.1.1 Primary Assembly

      Range
      13723772..13761804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005202256.3XP_005202313.1  secreted frizzled-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005202313.1

      UniProtKB/Swiss-Prot
      Q95117
      Conserved Domains (2) summary
      cd07441
      Location:32157
      CRD_SFRP3; Cysteine-rich domain of the secreted frizzled-related protein 3 (SFRP3, alias FRZB), a Wnt antagonist
      cd03581
      Location:188297
      NTR_Sfrp3_like; NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily; composed of proteins similar to human Sfrp3 and Sfrp4. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse functions ...
    2. XM_005202255.3XP_005202312.1  secreted frizzled-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005202312.1

      UniProtKB/Swiss-Prot
      Q95117
      Conserved Domains (2) summary
      cd07441
      Location:32157
      CRD_SFRP3; Cysteine-rich domain of the secreted frizzled-related protein 3 (SFRP3, alias FRZB), a Wnt antagonist
      cd03581
      Location:188297
      NTR_Sfrp3_like; NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily; composed of proteins similar to human Sfrp3 and Sfrp4. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse functions ...
    3. XM_015474623.1XP_015330109.1  secreted frizzled-related protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q95117
      Conserved Domains (2) summary
      cd07441
      Location:32157
      CRD_SFRP3; Cysteine-rich domain of the secreted frizzled-related protein 3 (SFRP3, alias FRZB), a Wnt antagonist
      cd03581
      Location:188297
      NTR_Sfrp3_like; NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily; composed of proteins similar to human Sfrp3 and Sfrp4. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse functions ...

    Alternate Btau_5.0.1

    Genomic

    1. NC_007300.6 Alternate Btau_5.0.1

      Range
      13757283..13794864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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