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    IRF3 interferon regulatory factor 3 [ Homo sapiens (human) ]

    Gene ID: 3661, updated on 20-Apr-2017
    Official Symbol
    IRF3provided by HGNC
    Official Full Name
    interferon regulatory factor 3provided by HGNC
    Primary source
    HGNC:HGNC:6118
    See related
    Ensembl:ENSG00000126456 MIM:603734; Vega:OTTHUMG00000183287
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IIAE7
    Summary
    This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
    Orthologs
    Location:
    19q13.33
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (49659569..49665875, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50162826..50169132, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene related RAS viral (r-ras) oncogene homolog Neighboring gene SR-related CTD associated factor 1 Neighboring gene BCL2 like 12 Neighboring gene protein arginine methyltransferase 1 Neighboring gene microRNA 5088 Neighboring gene adrenomedullin 5 (putative) Neighboring gene carnitine palmitoyltransferase 1C

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef myristoylation is required for the activation of IRF-3, leading to the synthesis of IFNbeta in monocytes-derived-macrophages PubMed
    nef The acidic cluster (residues 64-69) of HIV-1 Nef is required for IRF-3 activation and IFNbeta production PubMed
    Tat tat HIV-1 Tat-mediated downregulation of TRAF3 increases levels of phosphorylation of IRF3 and IRF7 in human microglial cells PubMed
    Vif vif HIV-1 Vpr and Vif proteins cooperate with HIV-1 Vpu to induce IRF3 cleavage, although their individual effects are weaker than those of Vpu PubMed
    vif Virion-associated accessory proteins Vif and Vpr can independently degrade IRF-3. Eleven lysine residues in the N-terminal domain of IRF-3 are important for the Vif and Vpr mediated degradation PubMed
    Vpr vpr HIV-1 Vpr and Vif proteins cooperate with HIV-1 Vpu to induce IRF3 cleavage, although their individual effects are weaker than those of Vpu PubMed
    vpr HIV-1 Vpr-mediated suppression of IFN induction is caused by failure of IRF-3 nucleus translocation PubMed
    vpr Virion-associated accessory proteins Vif and Vpr can independently degrade IRF-3. Eleven lysine residues in the N-terminal domain of IRF-3 are important for the Vif and Vpr mediated degradation PubMed
    Vpu vpu HIV-1 Vpr and Vif proteins cooperate with HIV-1 Vpu to induce IRF3 cleavage, although their individual effects are weaker than those of Vpu PubMed
    vpu Residue Asp121 is the primary site for Vpu-induced, caspase-mediated IRF3 cleavage, and the alternative site is residues Asp125 when Asp121 is mutated PubMed
    vpu Caspase-8 and caspase-3 activity are required for HIV-1 Vpu-induced cleavage of IRF3 and HIV-1 infection also induces caspase-mediated IRF3 cleavage PubMed
    vpu HIV-1 Vpu-induced cleavage of IRF3 is largely dependent on the ability of Vpu to interact with beta-TrCP, and mutation of the Vpu phosphorylation sites Ser52 and Ser56 greatly decreases the function of Vpu-induced IRF3 cleavage PubMed
    vpu HIV-1 Vpu co-localizes with IRF3 during HIV protein expression PubMed
    vpu Interaction of HIV-1 Vpu with IRF3 governs the innate immune response of the host cell to HIV-1 infection PubMed
    vpu HIV-1 Vpu forms a stable and specific complex with IRF3 in HIV-1-infected cells, resulting in its specific sequestration within the endo-lysosomal compartment PubMed
    capsid gag HIV-1 CA mutants N74D and P90A fail to bind to CPSF6 and cyclophilins (Nup358 and CypA), respectively, and trigger innate sensors, leading to nuclear translocation of NFkappaB and IRF3, production of type 1 IFN and induction of an antiviral state PubMed
    reverse transcriptase gag-pol The reverse-transcribed viral DNA by HIV-1 RT is the trigger of IRF3 activation and IFN-beta production in HIV-1 infected human monocytic cell line THP1 PubMed

    Go to the HIV-1, Human Interaction Database

    • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
      Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
    • Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, organism-specific biosystem (from REACTOME)
      Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, organism-specific biosystemCell stimulation with viral ds RNA leads to the activation of two IKK-related serine/threonine kinases, TBK1 and IKK-i which directly phosphorylate IRF3 and IRF7 promoting their dimerization and tran...
    • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
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    • Apoptosis, organism-specific biosystem (from WikiPathways)
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    • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
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    • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem (from REACTOME)
      Cytosolic sensors of pathogen-associated DNA, organism-specific biosystemPresence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon ...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
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    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
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    • IRF3 mediated activation of type 1 IFN, organism-specific biosystem (from REACTOME)
      IRF3 mediated activation of type 1 IFN, organism-specific biosystemInterferon regulatory factors (IRF) IRF-3 and IRF-7 are the major modulators of IFN gene expression in response to pathogenic molecules. The relative contribution of IRF3 and IRF7 depends on the sign...
    • IRF3-mediated induction of type I IFN, organism-specific biosystem (from REACTOME)
      IRF3-mediated induction of type I IFN, organism-specific biosystemTANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3) are central regulators of type-I interferon induction during bacterial or viral infection. TBK1 was found to form complexes with...
    • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
      ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
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    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
      Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production, organism-specific biosystem (from REACTOME)
      LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production, organism-specific biosystemLeucine-rich repeat flightless-interacting protein 1 (LRRFIP1) can bind exogenous double-stranded RNA and double-stranded DNA (Wilson SA et al. 1998; Yang P et al. 2010). LRRFIP1 was shown to mediate...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • MyD88-independent TLR3/TLR4 cascade, organism-specific biosystem (from REACTOME)
      MyD88-independent TLR3/TLR4 cascade, organism-specific biosystemMyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from ...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem (from REACTOME)
      Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystemAs with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune...
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • RIG-I-like Receptor Signaling, organism-specific biosystem (from WikiPathways)
      RIG-I-like Receptor Signaling, organism-specific biosystemViral pathogen RNA are recognized by host helicases called RIG-I-like receptors (RLRs) that include DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), SNW1, and DDX17. These RLR proteins then go on to initia...
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
    • Regulation of innate immune responses to cytosolic DNA, organism-specific biosystem (from REACTOME)
      Regulation of innate immune responses to cytosolic DNA, organism-specific biosystemInnate immune responses are coordinated and regulated to provide an efficient first line of defense against pathogens and at the same time to prevent host self-damage. Here we present some regulatory...
    • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Regulation of toll-like receptor signaling pathway, organism-specific biosystem
      Regulation of toll-like receptor signaling pathway
    • STING mediated induction of host immune responses, organism-specific biosystem (from REACTOME)
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    • TLR4 Signaling and Tolerance, organism-specific biosystem (from WikiPathways)
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    • TRAF3-dependent IRF activation pathway, organism-specific biosystem (from REACTOME)
      TRAF3-dependent IRF activation pathway, organism-specific biosystemIPS-1/MAVS/Cardif/VISA with its TRAF-interaction motif (TIM) directly interacts with TRAF3 and recruits TRAF3 to the RIG-I/MDA5 signaling complex. TRAF3 acts as a scaffold for the assembly of a signa...
    • TRAF6 mediated IRF7 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated IRF7 activation, organism-specific biosystemTRAF6 is crucial for both RIG-I- and MDA5-mediated antiviral responses. The absence of TRAF6 resulted in enhanced viral replication and a significant reduction in the production of type I IFNs and IL...
    • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
      TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
    • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
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    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
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    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
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    • Toll-like Receptor Signaling, organism-specific biosystem (from WikiPathways)
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    • Toll-like Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
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    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
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    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • ZBP1(DAI) mediated induction of type I IFNs, organism-specific biosystem (from REACTOME)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription cofactor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MDA-5 signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    TRIF-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to DNA damage stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to dsRNA IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    macrophage apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of type I interferon production TAS
    Traceable Author Statement
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interferon-alpha production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interferon-beta production TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of type I interferon production TAS
    Traceable Author Statement
    more info
     
    positive regulation of type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    programmed necrotic cell death IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of type I interferon production TAS
    Traceable Author Statement
    more info
     
    response to exogenous dsRNA IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    type I interferon biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    type I interferon signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    interferon regulatory factor 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031810.1 RefSeqGene

      Range
      5001..11307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001197122.1NP_001184051.1  interferon regulatory factor 3 isoform 2

      See identical proteins and their annotated locations for NP_001184051.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a longer protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      BC000660, BU859806, DA999381
      Consensus CDS
      CCDS59409.1
      UniProtKB/Swiss-Prot
      Q14653
      Related
      ENSP00000471896.1, OTTHUMP00000271317, ENST00000601291.5, OTTHUMT00000465960
      Conserved Domains (2) summary
      pfam00605
      Location:7110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:202326
      IRF-3; Interferon-regulatory factor 3
    2. NM_001197123.1NP_001184052.1  interferon regulatory factor 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as IRF3a) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC000660, BP347627, BU859806, DA999381, HM357932, HM357934
      UniProtKB/Swiss-Prot
      Q14653
      UniProtKB/TrEMBL
      E2GIM5, E2GIM7
      Conserved Domains (2) summary
      pfam10401
      Location:167345
      IRF-3; Interferon-regulatory factor 3
      cl00096
      Location:2175
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
    3. NM_001197124.1NP_001184053.1  interferon regulatory factor 3 isoform 4

      See identical proteins and their annotated locations for NP_001184053.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as IRF3e and IRF3-nirs3) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      BC000660, BU859806, DA999381, HM357935, HM357936
      Consensus CDS
      CCDS56099.1
      UniProtKB/Swiss-Prot
      Q14653
      UniProtKB/TrEMBL
      E2GIM8, E2GIM9
      Related
      ENSP00000471358.1, OTTHUMP00000271321, ENST00000599223.5, OTTHUMT00000465965
      Conserved Domains (2) summary
      pfam00605
      Location:7110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:200253
      IRF-3; Interferon-regulatory factor 3
    4. NM_001197125.1NP_001184054.1  interferon regulatory factor 3 isoform 5

      See identical proteins and their annotated locations for NP_001184054.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as IRF3f) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1. Both variants 5 and 6 encode the same isoform (5).
      Source sequence(s)
      BC000660, BU859806, DA999381, HM357937
      Consensus CDS
      CCDS59408.1
      UniProtKB/Swiss-Prot
      Q14653
      UniProtKB/TrEMBL
      E2GIM7, M0QYT9
      Related
      ENSP00000366339.5, ENST00000377135.8
      Conserved Domains (1) summary
      pfam10401
      Location:56234
      IRF-3; Interferon-regulatory factor 3
    5. NM_001197126.1NP_001184055.1  interferon regulatory factor 3 isoform 5

      See identical proteins and their annotated locations for NP_001184055.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6, also known as IRF3c) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1. Both variants 5 and 6 encode the same isoform (5).
      Source sequence(s)
      BC000660, BU859806, DA999381, HM357934
      Consensus CDS
      CCDS59408.1
      UniProtKB/Swiss-Prot
      Q14653
      UniProtKB/TrEMBL
      E2GIM7, M0QYT9
      Related
      ENSP00000470069.1, OTTHUMP00000271325, ENST00000599144.5, OTTHUMT00000465969
      Conserved Domains (1) summary
      pfam10401
      Location:56234
      IRF-3; Interferon-regulatory factor 3
    6. NM_001197127.1NP_001184056.1  interferon regulatory factor 3 isoform 6

      See identical proteins and their annotated locations for NP_001184056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7, also known as IRF3d) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also lacks an in-frame exon compared to variant 1. The encoded isoform (6) is shorter than isoform 1. Both variants 7 and 8 encode the same isoform (6).
      Source sequence(s)
      BC000660, BU859806, DA999381, HM357935
      Consensus CDS
      CCDS59407.1
      UniProtKB/Swiss-Prot
      Q14653
      UniProtKB/TrEMBL
      E2GIM8
      Related
      ENSP00000472700.1, OTTHUMP00000271323, ENST00000600022.5, OTTHUMT00000465967
      Conserved Domains (1) summary
      pfam10401
      Location:54107
      IRF-3; Interferon-regulatory factor 3
    7. NM_001197128.1NP_001184057.1  interferon regulatory factor 3 isoform 6

      See identical proteins and their annotated locations for NP_001184057.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8, also known as IRF3b) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also lacks an in-frame exon compared to variant 1. The encoded isoform (6) is shorter than isoform 1. Both variants 7 and 8 encode the same isoform (6).
      Source sequence(s)
      BC000660, BU859806, DA999381, HM357933, HM357935
      Consensus CDS
      CCDS59407.1
      UniProtKB/Swiss-Prot
      Q14653
      UniProtKB/TrEMBL
      E2GIM6, E2GIM8
      Related
      ENSP00000470512.1, OTTHUMP00000271324, ENST00000596765.5, OTTHUMT00000465968
      Conserved Domains (1) summary
      pfam10401
      Location:54107
      IRF-3; Interferon-regulatory factor 3
    8. NM_001571.5NP_001562.1  interferon regulatory factor 3 isoform 1

      See identical proteins and their annotated locations for NP_001562.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC011495, BU859806, DA999381, Z56281
      Consensus CDS
      CCDS12775.1
      UniProtKB/Swiss-Prot
      Q14653
      Related
      ENSP00000366344.3, OTTHUMP00000271318, ENST00000377139.7, OTTHUMT00000465961
      Conserved Domains (2) summary
      pfam00605
      Location:7110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:202380
      IRF-3; Interferon-regulatory factor 3

    RNA

    1. NR_045568.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA568913, AK292027, BU859806, DA938709, DA999381

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      49659569..49665875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006723197.1XP_006723260.1  interferon regulatory factor 3 isoform X1

      See identical proteins and their annotated locations for XP_006723260.1

      UniProtKB/Swiss-Prot
      Q14653
      Conserved Domains (2) summary
      pfam00605
      Location:7110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:202326
      IRF-3; Interferon-regulatory factor 3
    2. XM_017026766.1XP_016882255.1  interferon regulatory factor 3 isoform X2

      UniProtKB/Swiss-Prot
      Q14653
      Related
      ENSP00000469113.1, OTTHUMP00000271319, ENST00000597198.5, OTTHUMT00000465962
      Conserved Domains (2) summary
      pfam00605
      Location:7110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:202380
      IRF-3; Interferon-regulatory factor 3
    3. XM_006723202.2XP_006723265.1  interferon regulatory factor 3 isoform X4

      See identical proteins and their annotated locations for XP_006723265.1

      Conserved Domains (1) summary
      pfam10401
      Location:56180
      IRF-3; Interferon-regulatory factor 3
    4. XM_017026767.1XP_016882256.1  interferon regulatory factor 3 isoform X2

      UniProtKB/Swiss-Prot
      Q14653
      Related
      ENSP00000310127.6, OTTHUMP00000271314, ENST00000309877.11, OTTHUMT00000465957
      Conserved Domains (2) summary
      pfam00605
      Location:7110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:202380
      IRF-3; Interferon-regulatory factor 3
    5. XM_006723198.1XP_006723261.1  interferon regulatory factor 3 isoform X1

      See identical proteins and their annotated locations for XP_006723261.1

      UniProtKB/Swiss-Prot
      Q14653
      Related
      ENSP00000470431.1, OTTHUMP00000271315, ENST00000600911.5, OTTHUMT00000465958
      Conserved Domains (2) summary
      pfam00605
      Location:7110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:202326
      IRF-3; Interferon-regulatory factor 3
    6. XM_006723201.1XP_006723264.1  interferon regulatory factor 3 isoform X4

      See identical proteins and their annotated locations for XP_006723264.1

      Conserved Domains (1) summary
      pfam10401
      Location:56180
      IRF-3; Interferon-regulatory factor 3
    7. XM_006723200.1XP_006723263.1  interferon regulatory factor 3 isoform X3

      Conserved Domains (2) summary
      pfam10401
      Location:167291
      IRF-3; Interferon-regulatory factor 3
      cl00096
      Location:2175
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...

    RNA

    1. XR_001753678.1 RNA Sequence

    2. XR_001753677.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      50164615..50170921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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