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    DDR1 discoidin domain receptor tyrosine kinase 1 [ Homo sapiens (human) ]

    Gene ID: 780, updated on 5-Nov-2017
    Official Symbol
    DDR1provided by HGNC
    Official Full Name
    discoidin domain receptor tyrosine kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:2730
    See related
    Ensembl:ENSG00000204580 MIM:600408; Vega:OTTHUMG00000031236
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A
    Summary
    Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
    Orthologs
    Location:
    6p21.33
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (30880909..30900156)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30850694..30867933)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2570 Neighboring gene RNA, 7SK small nuclear pseudogene 186 Neighboring gene microRNA 4640 Neighboring gene general transcription factor IIH subunit 4 Neighboring gene valyl-tRNA synthetase 2, mitochondrial

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common genetic variation and the control of HIV-1 in humans.
    NHGRI GWA Catalog
    Genetic predictors of medically refractory ulcerative colitis.
    NHGRI GWA Catalog
    Seven new loci associated with age-related macular degeneration.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    collagen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase collagen receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    axon development IEA
    Inferred from Electronic Annotation
    more info
     
    branching involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    collagen-activated tyrosine kinase receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen-activated tyrosine kinase receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ear development IEA
    Inferred from Electronic Annotation
    more info
     
    embryo implantation IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix organization TAS
    Traceable Author Statement
    more info
     
    lactation IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection extension IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smooth muscle cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    wound healing, spreading of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    epithelial discoidin domain-containing receptor 1
    Names
    CD167 antigen-like family member A
    PTK3A protein tyrosine kinase 3A
    cell adhesion kinase
    mammary carcinoma kinase 10
    neuroepithelial tyrosine kinase
    neurotrophic tyrosine kinase, receptor, type 4
    protein-tyrosine kinase RTK-6
    tyrosine kinase DDR
    tyrosine-protein kinase CAK
    NP_001189450.1
    NP_001189451.1
    NP_001189452.1
    NP_001284581.1
    NP_001284582.1
    NP_001284583.1
    NP_001945.3
    NP_054699.2
    NP_054700.2
    XP_006715248.1
    XP_011513184.1
    XP_011513185.1
    XP_011513186.1
    XP_011513187.1
    XP_011513188.1
    XP_011513189.1
    XP_011513190.1
    XP_016866757.1
    XP_016866758.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029066.1 RefSeqGene

      Range
      5001..21073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202521.1NP_001189450.1  epithelial discoidin domain-containing receptor 1 isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is missing an internal coding exon compared to variant 1. This results in a frame-shift, and early translation termination, rendering this transcript a candidate for nonsense-mediated mRNA decay (NMD). However, the encoded isoform (4, also known as DDR1d) is represented as it has been detected in vivo in several colon carcinoma cell lines (PMID:11344127). This isoform is truncated and lacks the catalytic tyrosine kinase domain, therefore, most likely lacks intrinsic tyrosine kinase activity. It may function in some other regulatory capacity.
      Source sequence(s)
      AF353182, BC008716, L20817
      UniProtKB/Swiss-Prot
      Q08345
      UniProtKB/TrEMBL
      Q96T62
      Conserved Domains (2) summary
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:60184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    2. NM_001202522.1NP_001189451.1  epithelial discoidin domain-containing receptor 1 isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) is missing an internal coding exon, and uses an alternate acceptor splice site at one of the coding exons compared to variant 1. This results in localized frame-shift, and a shorter isoform (5, also known as DDR1e) compared to isoform 1. This isoform lacks the ATP binding site, therefore, most likely lacks intrinsic tyrosine kinase activity. It may function in some other regulatory capacity.
      Source sequence(s)
      AF353183, BC008716, L20817
      Consensus CDS
      CCDS75419.1
      UniProtKB/Swiss-Prot
      Q08345
      UniProtKB/TrEMBL
      A0A0A0MSX3, Q96T61
      Related
      ENSP00000405998.2, ENST00000446312.5
      Conserved Domains (4) summary
      smart00221
      Location:498759
      STYKc; Protein kinase; unclassified specificity
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:60184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl21453
      Location:478761
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001202523.1NP_001189452.1  epithelial discoidin domain-containing receptor 1 isoform 6 precursor

      See identical proteins and their annotated locations for NP_001189452.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame upstream start codon, and a longer isoform (6) with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK294793, BC008716, DC369107
      Consensus CDS
      CCDS56411.1
      UniProtKB/Swiss-Prot
      Q08345
      Related
      ENSP00000422442.1, OTTHUMP00000222080, ENST00000508312.5, OTTHUMT00000369045
      Conserved Domains (4) summary
      cd05096
      Location:585888
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      smart00221
      Location:591886
      STYKc; Protein kinase; unclassified specificity
      smart00231
      Location:48203
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:78202
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    4. NM_001297652.1NP_001284581.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001284581.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. It encodes isoform 1 (also known as DDR1a). Variants 1, 7, and 8 encode the same isoform (1).
      Source sequence(s)
      AK291621, AK294793, BC008716, DA461082
      Consensus CDS
      CCDS4690.1
      UniProtKB/Swiss-Prot
      Q08345
      UniProtKB/TrEMBL
      A0A024RCQ1
      Related
      ENSP00000407699.2, OTTHUMP00000164863, ENST00000418800.6, OTTHUMT00000257572
      Conserved Domains (2) summary
      cd05096
      Location:567870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    5. NM_001297653.1NP_001284582.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001284582.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. It encodes isoform 1 (also known as DDR1a). Variants 1, 7, and 8 encode the same isoform (1).
      Source sequence(s)
      BC008716, L57508
      Consensus CDS
      CCDS4690.1
      UniProtKB/Swiss-Prot
      Q08345
      UniProtKB/TrEMBL
      A0A024RCQ1
      Related
      ENSP00000365753.3, OTTHUMP00000029344, ENST00000376569.7, OTTHUMT00000076491
      Conserved Domains (2) summary
      cd05096
      Location:567870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    6. NM_001297654.1NP_001284583.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001284583.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) contains an additional in-frame coding exon and differs in the 5' UTR compared to variant 1, resulting in a longer isoform (2, also known as DDR1b) with a 37 aa protein segment not found in isoform 1. Variants 2 and 9 encode the same isoform (2).
      Source sequence(s)
      BC008716, L20817
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      Q08345
      UniProtKB/TrEMBL
      A0A024RCL1
      Related
      ENSP00000365752.3, OTTHUMP00000029345, ENST00000376568.7, OTTHUMT00000076492
      Conserved Domains (4) summary
      cd05096
      Location:604907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      smart00219
      Location:610905
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:60184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    7. NM_001954.4NP_001945.3  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001945.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1 (also known as DDR1a). Variants 1, 7, and 8 encode the same isoform (1).
      Source sequence(s)
      BC008716, BC070070
      Consensus CDS
      CCDS4690.1
      UniProtKB/Swiss-Prot
      Q08345
      UniProtKB/TrEMBL
      A0A024RCQ1
      Related
      ENSP00000365754.4, ENST00000376570.8
      Conserved Domains (2) summary
      cd05096
      Location:567870
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:60184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    8. NM_013993.2NP_054699.2  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_054699.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional in-frame coding exon compared to variant 1, resulting in a longer isoform (2, also known as DDR1b) with a 37 aa protein segment not found in isoform 1. Variants 2 and 9 encode the same isoform (2).
      Source sequence(s)
      BC008716, CN362335, L11315
      Consensus CDS
      CCDS34385.1
      UniProtKB/Swiss-Prot
      Q08345
      UniProtKB/TrEMBL
      A0A024RCL1
      Related
      ENSP00000405039.1, ENST00000452441.5
      Conserved Domains (4) summary
      cd05096
      Location:604907
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      smart00219
      Location:610905
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:60184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    9. NM_013994.2NP_054700.2  epithelial discoidin domain-containing receptor 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_054700.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an additional in-frame coding exon, and uses an alternate in-frame acceptor splice site at one of the coding exons compared to variant 1. This results in the longest isoform (3, also known as DDR1c) with additional protein segments not found in isoform 1.
      Source sequence(s)
      BC008716, BI193181, L11315, Z29093
      Consensus CDS
      CCDS47396.1
      UniProtKB/Swiss-Prot
      Q08345
      UniProtKB/TrEMBL
      A0A024RCJ0
      Related
      ENSP00000427552.1, OTTHUMP00000164867, ENST00000513240.5, OTTHUMT00000257577
      Conserved Domains (4) summary
      cd05096
      Location:604913
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      smart00219
      Location:610911
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:60184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      30880909..30900156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514887.1XP_011513189.1  epithelial discoidin domain-containing receptor 1 isoform X5

      See identical proteins and their annotated locations for XP_011513189.1

      UniProtKB/TrEMBL
      A0A024RCJ0
      Conserved Domains (4) summary
      cd05096
      Location:604913
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      smart00219
      Location:610911
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:60184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    2. XM_017011269.1XP_016866758.1  epithelial discoidin domain-containing receptor 1 isoform X4

    3. XM_011514884.1XP_011513186.1  epithelial discoidin domain-containing receptor 1 isoform X5

      See identical proteins and their annotated locations for XP_011513186.1

      UniProtKB/TrEMBL
      A0A024RCJ0
      Conserved Domains (4) summary
      cd05096
      Location:604913
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      smart00219
      Location:610911
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:60184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    4. XM_011514886.1XP_011513188.1  epithelial discoidin domain-containing receptor 1 isoform X5

      See identical proteins and their annotated locations for XP_011513188.1

      UniProtKB/TrEMBL
      A0A024RCJ0
      Conserved Domains (4) summary
      cd05096
      Location:604913
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      smart00219
      Location:610911
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:60184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    5. XM_011514883.1XP_011513185.1  epithelial discoidin domain-containing receptor 1 isoform X5

      See identical proteins and their annotated locations for XP_011513185.1

      UniProtKB/TrEMBL
      A0A024RCJ0
      Conserved Domains (4) summary
      cd05096
      Location:604913
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      smart00219
      Location:610911
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:60184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    6. XM_017011268.1XP_016866757.1  epithelial discoidin domain-containing receptor 1 isoform X5

      UniProtKB/TrEMBL
      A0A024RCJ0
      Conserved Domains (4) summary
      cd05096
      Location:604913
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      smart00219
      Location:610911
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:60184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    7. XM_011514885.1XP_011513187.1  epithelial discoidin domain-containing receptor 1 isoform X5

      See identical proteins and their annotated locations for XP_011513187.1

      UniProtKB/TrEMBL
      A0A024RCJ0
      Conserved Domains (4) summary
      cd05096
      Location:604913
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      smart00219
      Location:610911
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:60184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    8. XM_011514882.2XP_011513184.1  epithelial discoidin domain-containing receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_011513184.1

      Conserved Domains (4) summary
      cd05096
      Location:622931
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      smart00221
      Location:628929
      STYKc; Protein kinase; unclassified specificity
      smart00231
      Location:48203
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:78202
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    9. XM_006715185.2XP_006715248.1  epithelial discoidin domain-containing receptor 1 isoform X2

      See identical proteins and their annotated locations for XP_006715248.1

      Conserved Domains (4) summary
      cd05096
      Location:622925
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      smart00221
      Location:628923
      STYKc; Protein kinase; unclassified specificity
      smart00231
      Location:48203
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:78202
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    10. XM_011514888.2XP_011513190.1  epithelial discoidin domain-containing receptor 1 isoform X3

      See identical proteins and their annotated locations for XP_011513190.1

      Conserved Domains (4) summary
      cd05096
      Location:585894
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      smart00221
      Location:591892
      STYKc; Protein kinase; unclassified specificity
      smart00231
      Location:48203
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:78202
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    Reference GRCh38.p7 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p7 ALT_REF_LOCI_1

      Range
      2214565..2218962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p7 ALT_REF_LOCI_2

      Range
      2362382..2379927
      Download
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    Reference GRCh38.p7 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p7 ALT_REF_LOCI_3

      Range
      2138908..2156466
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    Reference GRCh38.p7 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p7 ALT_REF_LOCI_4

      Range
      2192855..2210394
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    Reference GRCh38.p7 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p7 ALT_REF_LOCI_5

      Range
      2226762..2249066
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    Reference GRCh38.p7 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p7 ALT_REF_LOCI_6

      Range
      2137781..2155326
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      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      30852569..30870114
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