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    CAV1 caveolin 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 403980, updated on 8-Sep-2017
    Official Symbol
    CAV1provided by VGNC
    Official Full Name
    caveolin 1provided by VGNC
    See related
    Ensembl:ENSCAFG00000003404
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    Location:
    chromosome: 14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    105 current CanFam3.1 (GCF_000002285.3) 14 NC_006596.3 (55458934..55494563)

    Chromosome 14 - NC_006596.3Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein E pseudogene Neighboring gene uncharacterized LOC111098847 Neighboring gene caveolin 2 Neighboring gene MET proto-oncogene, receptor tyrosine kinase Neighboring gene uncharacterized LOC111098848 Neighboring gene uncharacterized LOC106559678

    Genomic Sequence:
    NC_006596.3 Chromosome 14 Reference CanFam3.1 Primary Assembly

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Rac GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    inward rectifier potassium channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    ion channel binding IEA
    Inferred from Electronic Annotation
    more info
     
    nitric-oxide synthase binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex scaffold activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    structural molecule activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    T cell costimulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    angiotensin-activated signaling pathway involved in heart process IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    caveola assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    caveolin-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to exogenous dsRNA IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hyperoxia IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    inactivation of MAPK activity IEA
    Inferred from Electronic Annotation
    more info
     
    lactation IEA
    Inferred from Electronic Annotation
    more info
     
    lipid storage IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland involution IEA
    Inferred from Electronic Annotation
    more info
     
    membrane depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of anoikis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of necroptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of nitric-oxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of peptidyl-tyrosine autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of pinocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
     
    nitric oxide homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of calcium ion transport into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell adhesion molecule production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gap junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of toll-like receptor 3 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    posttranscriptional regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to plasma membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor internalization involved in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    receptor-mediated endocytosis of virus by host cell IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell communication by electrical coupling involved in cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of entry of bacterium into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of heart rate by cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of membrane repolarization during action potential IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ruffle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of the force of heart contraction by chemical signal IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ventricular cardiac muscle cell action potential IEA
    Inferred from Electronic Annotation
    more info
     
    response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    VCP-NPL4-UFD1 AAA ATPase complex IEA
    Inferred from Electronic Annotation
    more info
     
    acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cilium IEA
    Inferred from Electronic Annotation
    more info
     
    endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    exocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    caveolin-1
    Names
    vesicular integral-membrane protein VIP21

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003296.1NP_001003296.1  caveolin-1

      See identical proteins and their annotated locations for NP_001003296.1

      Status: PROVISIONAL

      Source sequence(s)
      U47060
      UniProtKB/Swiss-Prot
      P33724
      Related
      ENSCAFP00000005060.3, ENSCAFT00000005462.3
      Conserved Domains (1) summary
      pfam01146
      Location:43175
      Caveolin; Caveolin

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CanFam3.1 Primary Assembly

    Genomic

    1. NC_006596.3 Reference CanFam3.1 Primary Assembly

      Range
      55458934..55494563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014118875.2XP_013974350.1  caveolin-1 isoform X1

      UniProtKB/Swiss-Prot
      P33724
      Conserved Domains (1) summary
      pfam01146
      Location:12144
      Caveolin; Caveolin
    2. XM_005628347.3XP_005628404.1  caveolin-1 isoform X1

      UniProtKB/Swiss-Prot
      P33724
      Conserved Domains (1) summary
      pfam01146
      Location:12144
      Caveolin; Caveolin
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