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    ITGA6 integrin subunit alpha 6 [ Gallus gallus (chicken) ]

    Gene ID: 396226, updated on 2-Apr-2017
    Symbol
    ITGA6provided by CGNC
    Full Name
    integrin subunit alpha 6provided by CGNC
    Primary source
    CGNC:7117
    See related
    Ensembl:ENSGALG00000034007
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    Location:
    chromosome: 7
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    103 current Gallus_gallus-5.0 (GCF_000002315.4) 7 NC_006094.4 (17797914..17838399, complement)
    102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 7 NC_006094.3 (17214612..17252863, complement)

    Chromosome 7 - NC_006094.4Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 9B Neighboring gene uncharacterized LOC101748000 Neighboring gene pyruvate dehydrogenase kinase 1 Neighboring gene distal-less homeobox 2 Neighboring gene distal-less homeobox 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to insulin-like growth factor I binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to neuregulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    integrin alpha-6
    Names
    VLA-6
    integrin alpha 6 subunit
    integrin, alpha 6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205289.1NP_990620.1  integrin alpha-6 precursor

      See identical proteins and their annotated locations for NP_990620.1

      Status: PROVISIONAL

      Source sequence(s)
      X56559
      UniProtKB/Swiss-Prot
      P26007
      Related
      ENSGALP00000056234.1, ENSGALT00000081430.2
      Conserved Domains (2) summary
      smart00191
      Location:367419
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:461938
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Gallus_gallus-5.0 Primary Assembly

    Genomic

    1. NC_006094.4 Reference Gallus_gallus-5.0 Primary Assembly

      Range
      17797914..17838399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015289641.1XP_015145127.1  integrin alpha-6 isoform X1

      UniProtKB/TrEMBL
      A0A1L1RZY6
      Related
      ENSGALP00000064434.1, ENSGALT00000084249.1
      Conserved Domains (2) summary
      smart00191
      Location:367419
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:461938
      Integrin_alpha2; Integrin alpha
    2. XM_015289643.1XP_015145129.1  integrin alpha-6 isoform X2

      UniProtKB/TrEMBL
      A0A1D5PK42
      Related
      ENSGALP00000053194.1, ENSGALT00000057481.1
      Conserved Domains (2) summary
      smart00191
      Location:267319
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:361838
      Integrin_alpha2; Integrin alpha
    3. XM_015289642.1XP_015145128.1  integrin alpha-6 isoform X2

      UniProtKB/TrEMBL
      A0A1D5PK42
      Conserved Domains (2) summary
      smart00191
      Location:267319
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:361838
      Integrin_alpha2; Integrin alpha
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