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    Adar adenosine deaminase, RNA-specific [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81635, updated on 3-Apr-2018
    Official Symbol
    Adarprovided by RGD
    Official Full Name
    adenosine deaminase, RNA-specificprovided by RGD
    Primary source
    RGD:71099
    See related
    Ensembl:ENSRNOG00000020744
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    converts adenosine to inosine in double stranded RNA [RGD, Feb 2006]
    Expression
    Biased expression in Spleen (RPKM 163.5), Heart (RPKM 142.4) and 9 other tissues See more
    Orthologs
    Location:
    2q34
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189045551..189085448)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (208468426..208506275)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene phosphomevalonate kinase Neighboring gene potassium calcium-activated channel subfamily N member 3 Neighboring gene cholinergic receptor nicotinic beta 2 subunit Neighboring gene ubiquitin conjugating enzyme E2 Q1

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016
    • C6 deamination of adenosine, organism-specific biosystem (from REACTOME)
      C6 deamination of adenosine, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Formation of editosomes by ADAR proteins, organism-specific biosystem (from REACTOME)
      Formation of editosomes by ADAR proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • mRNA Editing, organism-specific biosystem (from REACTOME)
      mRNA Editing, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • mRNA Editing: A to I Conversion, organism-specific biosystem (from REACTOME)
      mRNA Editing: A to I Conversion, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded RNA adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded RNA adenosine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    adenosine to inosine editing IEA
    Inferred from Electronic Annotation
    more info
     
    adenosine to inosine editing ISO
    Inferred from Sequence Orthology
    more info
     
    adenosine to inosine editing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    base conversion or substitution editing ISO
    Inferred from Sequence Orthology
    more info
     
    biological_process ND
    No biological Data available
    more info
     
    cellular response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    definitive hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    definitive hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    hematopoietic stem cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic stem cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    miRNA loading onto RISC involved in gene silencing by miRNA IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA loading onto RISC involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of RNA interference IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of RNA interference ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity by regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase activity by regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity by regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of viral genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    pre-miRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    production of miRNAs involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to interferon-alpha IEA
    Inferred from Electronic Annotation
    more info
     
    response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
     
    response to interferon-alpha ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    somatic diversification of immune receptors via somatic mutation IEA
    Inferred from Electronic Annotation
    more info
     
    somatic diversification of immune receptors via somatic mutation ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    supraspliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     
    supraspliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    supraspliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    double-stranded RNA-specific adenosine deaminase
    Names
    DRADA
    NP_112268.1
    XP_006232836.1
    XP_006232837.1
    XP_006232838.1
    XP_006232839.1
    XP_006232840.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031006.1NP_112268.1  double-stranded RNA-specific adenosine deaminase

      See identical proteins and their annotated locations for NP_112268.1

      Status: PROVISIONAL

      Source sequence(s)
      U18942
      UniProtKB/Swiss-Prot
      P55266
      Related
      ENSRNOP00000028181.2, ENSRNOT00000028181.5
      Conserved Domains (4) summary
      smart00358
      Location:454519
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:7851168
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:137203
      z-alpha; Adenosine deaminase z-alpha domain
      cl02659
      Location:245309
      z-alpha; Adenosine deaminase z-alpha domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      189045551..189085448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232774.3XP_006232836.1  double-stranded RNA-specific adenosine deaminase isoform X1

      Conserved Domains (4) summary
      smart00358
      Location:462527
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:7931176
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:145211
      z-alpha; Adenosine deaminase z-alpha domain
      cl02659
      Location:253317
      z-alpha; Adenosine deaminase z-alpha domain
    2. XM_006232775.3XP_006232837.1  double-stranded RNA-specific adenosine deaminase isoform X2

      Conserved Domains (4) summary
      smart00358
      Location:462527
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:7671150
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:145211
      z-alpha; Adenosine deaminase z-alpha domain
      cl02659
      Location:253317
      z-alpha; Adenosine deaminase z-alpha domain
    3. XM_006232777.3XP_006232839.1  double-stranded RNA-specific adenosine deaminase isoform X4

      See identical proteins and their annotated locations for XP_006232839.1

      Conserved Domains (3) summary
      smart00358
      Location:209274
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:540923
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cl02659
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
    4. XM_006232778.2XP_006232840.1  double-stranded RNA-specific adenosine deaminase isoform X4

      See identical proteins and their annotated locations for XP_006232840.1

      Conserved Domains (3) summary
      smart00358
      Location:209274
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:540923
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cl02659
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
    5. XM_006232776.3XP_006232838.1  double-stranded RNA-specific adenosine deaminase isoform X3

      Conserved Domains (4) summary
      smart00358
      Location:454519
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:7591142
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:137203
      z-alpha; Adenosine deaminase z-alpha domain
      cl02659
      Location:245309
      z-alpha; Adenosine deaminase z-alpha domain

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      169097840..169118615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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