Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    KLK1 kallikrein 1 [ Homo sapiens (human) ]

    Gene ID: 3816, updated on 4-Sep-2016
    Official Symbol
    KLK1provided by HGNC
    Official Full Name
    kallikrein 1provided by HGNC
    Primary source
    HGNC:HGNC:6357
    See related
    Ensembl:ENSG00000167748 HPRD:01003; MIM:147910; Vega:OTTHUMG00000182876
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hK1; KLKR; Klk6
    Summary
    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    19q13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (50819146..50823787, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51322402..51327043, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene chromosome 19 open reading frame 48 Neighboring gene small nucleolar RNA, C/D box 88C Neighboring gene uncharacterized LOC284365 Neighboring gene uncharacterized LOC105372441 Neighboring gene kallikrein related peptidase 15 Neighboring gene kallikrein related peptidase 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    serine-type endopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    kallikrein-1
    Names
    glandular kallikrein 1
    kallikrein 1, renal/pancreas/salivary
    kallikrein serine protease 1
    kidney/pancreas/salivary gland kallikrein
    tissue kallikrein
    NP_002248.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012094.1 RefSeqGene

      Range
      5001..9642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002257.3NP_002248.1  kallikrein-1 preproprotein

      See identical proteins and their annotated locations for NP_002248.1

      Status: REVIEWED

      Source sequence(s)
      BP323011, CA772631, X13561
      Consensus CDS
      CCDS12804.1
      UniProtKB/Swiss-Prot
      P06870
      Related
      ENSP00000301420, OTTHUMP00000270391, ENST00000301420, OTTHUMT00000464135
      Conserved Domains (2) summary
      smart00020
      Location:24254
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:25257
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      50819146..50823787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526942.1XP_011525244.1  

      Conserved Domains (2) summary
      smart00020
      Location:13152
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:15155
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      51324194..51328835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center