Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    ME1 malic enzyme 1 [ Homo sapiens (human) ]

    Gene ID: 4199, updated on 22-Apr-2017
    Official Symbol
    ME1provided by HGNC
    Official Full Name
    malic enzyme 1provided by HGNC
    Primary source
    HGNC:HGNC:6983
    See related
    Ensembl:ENSG00000065833 MIM:154250; Vega:OTTHUMG00000015111
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MES; HUMNDME
    Summary
    This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    6q14.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (83210389..83431219, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (83920108..84140938, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene dopey family member 1 Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene protease, serine 35 Neighboring gene synaptosome associated protein 91

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Carbon metabolism, organism-specific biosystem (from KEGG)
      Carbon metabolism, organism-specific biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
    • Carbon metabolism, conserved biosystem (from KEGG)
      Carbon metabolism, conserved biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • NRF2 pathway, organism-specific biosystem (from WikiPathways)
      NRF2 pathway, organism-specific biosystemNRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
    • PPAR signaling pathway, organism-specific biosystem (from KEGG)
      PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPAR signaling pathway, conserved biosystem (from KEGG)
      PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
      PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • Pyruvate metabolism, organism-specific biosystem (from KEGG)
      Pyruvate metabolism, organism-specific biosystem
      Pyruvate metabolism
    • Pyruvate metabolism, conserved biosystem (from KEGG)
      Pyruvate metabolism, conserved biosystem
      Pyruvate metabolism
    • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ADP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    NAD binding TAS
    Traceable Author Statement
    more info
    PubMed 
    NADP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    electron carrier activity TAS
    Traceable Author Statement
    more info
    PubMed 
    malate dehydrogenase (decarboxylating) (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    malate dehydrogenase (decarboxylating) (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    malate dehydrogenase (decarboxylating) (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    malic enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    malic enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    manganese ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxaloacetate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    NADP biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    carbohydrate metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    malate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of NADP metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to carbohydrate TAS
    Traceable Author Statement
    more info
    PubMed 
    response to hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    NADP-dependent malic enzyme
    Names
    Malic enzyme, cytoplasmic
    NADP-ME
    malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))
    malic enzyme 1, NADP(+)-dependent, cytosolic
    malic enzyme 1, soluble
    pyruvic-malic carboxylase
    NP_002386.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002395.5NP_002386.1  NADP-dependent malic enzyme

      See identical proteins and their annotated locations for NP_002386.1

      Status: REVIEWED

      Source sequence(s)
      AL049699, BC025246, DA520723, KF458214
      Consensus CDS
      CCDS34492.1
      UniProtKB/Swiss-Prot
      P48163
      Related
      ENSP00000358719.3, OTTHUMP00000016792, ENST00000369705.3, OTTHUMT00000041350
      Conserved Domains (3) summary
      cd05312
      Location:270547
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:11551
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:79260
      malic; Malic enzyme, N-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      83210389..83431219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535836.2XP_011534138.1  NADP-dependent malic enzyme isoform X1

      See identical proteins and their annotated locations for XP_011534138.1

      UniProtKB/Swiss-Prot
      P48163
      Conserved Domains (3) summary
      cd05312
      Location:195472
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      COG0281
      Location:5474
      SfcA; Malic enzyme [Energy production and conversion]
      pfam00390
      Location:4185
      malic; Malic enzyme, N-terminal domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      84017801..84238482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center