Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    FCER2 Fc fragment of IgE receptor II [ Homo sapiens (human) ]

    Gene ID: 2208, updated on 8-May-2017
    Official Symbol
    FCER2provided by HGNC
    Official Full Name
    Fc fragment of IgE receptor IIprovided by HGNC
    Primary source
    HGNC:HGNC:3612
    See related
    Ensembl:ENSG00000104921 MIM:151445; Vega:OTTHUMG00000182517
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2
    Summary
    The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
    Orthologs
    Location:
    19p13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (7688757..7702755, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7753643..7767036, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene mast cell expressed membrane protein 1 Neighboring gene trafficking protein particle complex 5 Neighboring gene uncharacterized LOC105372262 Neighboring gene C-type lectin domain family 4 member G

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of Fc fragment of IgE, low affinity receptor II (FCER2; CD23) in human B cells PubMed
    env CD23 protein membrane expression is upregulated by HIV-1 gp120 and this upregulation induces the production of nitric oxide (NO) and IL-1beta PubMed
    Envelope surface glycoprotein gp160, precursor env Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells PubMed
    Nef nef In macrophages, activation of CD40 or expression of HIV-1 Nef induces the release of sCD23 and sICAM, which mediate effects on T lymphocytes, rendering them permissive to HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL4-mediated signaling events, organism-specific biosystem
      IL4-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-10 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-10 signaling, organism-specific biosystemInterleukin-10 (IL10) was originally described as a factor named cytokine synthesis inhibitory factor that inhibited T-helper (Th) 1 activation and Th1 cytokine production (Fiorentino et al. 1989). ...
    • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
    • NOTCH2 intracellular domain regulates transcription, organism-specific biosystem (from REACTOME)
      NOTCH2 intracellular domain regulates transcription, organism-specific biosystemIn the nucleus, NICD2 forms a complex with RBPJ (CBF1, CSL) and MAML (mastermind). NICD2:RBPJ:MAML complex activates transcription from RBPJ-binding promoter elements (RBEs) (Wu et al. 2000). Besides...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH2, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH2, organism-specific biosystemNOTCH2 is activated by binding Delta-like and Jagged ligands (DLL/JAG) expressed in trans on neighboring cells (Shimizu et al. 1999, Shimizu et al. 2000, Hicks et al. 2000, Ji et al. 2004). In trans ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    IgE binding IEA
    Inferred from Electronic Annotation
    more info
     
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    low affinity immunoglobulin epsilon Fc receptor
    Names
    C-type lectin domain family 4, member J
    CD23 antigen
    Fc epsilon receptor II
    Fc fragment of IgE, low affinity II, receptor for (CD23)
    fc-epsilon-RII
    immunoglobulin E-binding factor
    immunoglobulin epsilon-chain
    lymphocyte IgE receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029554.1 RefSeqGene

      Range
      5001..18390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001207019.2NP_001193948.2  low affinity immunoglobulin epsilon Fc receptor isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b, also known as CD23b) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by data in PubMed IDs 12379312 and 15843555.
      Source sequence(s)
      AC008763, BC014108, DB333832
      UniProtKB/Swiss-Prot
      P06734
      UniProtKB/TrEMBL
      K3W4U1
      Related
      ENSP00000353178.4, ENST00000360067.8
      Conserved Domains (2) summary
      smart00034
      Location:162281
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      cl23720
      Location:76152
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_001220500.1NP_001207429.1  low affinity immunoglobulin epsilon Fc receptor isoform a

      See identical proteins and their annotated locations for NP_001207429.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate donor splice site in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a, also known as CD23a).
      Source sequence(s)
      BC062591, DA957269, DB333832
      Consensus CDS
      CCDS12184.1
      UniProtKB/Swiss-Prot
      P06734
      Related
      ENSP00000471974.1, OTTHUMP00000269468, ENST00000597921.5, OTTHUMT00000461833
      Conserved Domains (2) summary
      smart00034
      Location:163282
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      cl23720
      Location:77153
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. NM_002002.4NP_001993.2  low affinity immunoglobulin epsilon Fc receptor isoform a

      See identical proteins and their annotated locations for NP_001993.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a, also known as CD23a). Both variants 1 and 3 encode the same isoform.
      Source sequence(s)
      BC014108, DA957269, DB333832
      Consensus CDS
      CCDS12184.1
      UniProtKB/Swiss-Prot
      P06734
      Related
      ENSP00000264072.6, OTTHUMP00000269467, ENST00000346664.9, OTTHUMT00000461832
      Conserved Domains (2) summary
      smart00034
      Location:163282
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      cl23720
      Location:77153
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      7688757..7702755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272462.4XP_005272519.1  low affinity immunoglobulin epsilon Fc receptor isoform X1

      See identical proteins and their annotated locations for XP_005272519.1

      UniProtKB/Swiss-Prot
      P06734
      Conserved Domains (2) summary
      smart00034
      Location:163282
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      cl23720
      Location:77153
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      7753396..7766778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center