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    Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) [ Mus musculus (house mouse) ]

    Gene ID: 230979, updated on 7-May-2017
    Official Symbol
    Tnfrsf14provided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)provided by MGI
    Primary source
    MGI:MGI:2675303
    See related
    Ensembl:ENSMUSG00000042333 Vega:OTTMUSG00000010461
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atar; HveA; Hvem; Tnfrs14
    Orthologs
    Location:
    4; 4 E2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (154921442..154928620, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (154296319..154302186, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 213, member B Neighboring gene predicted gene, 42362 Neighboring gene hairy and enhancer of split 5 (Drosophila) Neighboring gene predicted gene, 42363 Neighboring gene pantothenate kinase 4

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC123498, MGC123499

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tumor necrosis factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of alpha-beta T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytokine secretion involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    tumor necrosis factor receptor superfamily member 14
    Names
    herpes virus entry mediator

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178931.2NP_849262.1  tumor necrosis factor receptor superfamily member 14 precursor

      See identical proteins and their annotated locations for NP_849262.1

      Status: PROVISIONAL

      Source sequence(s)
      AY264405
      Consensus CDS
      CCDS19017.1
      UniProtKB/TrEMBL
      Q80WM9
      Related
      ENSMUSP00000045240.5, OTTMUSP00000011488, ENSMUST00000045919.11, OTTMUST00000025077
      Conserved Domains (3) summary
      cd00185
      Location:138201
      TNFRSF; CRD2 [structural motif]
      cd10582
      Location:42142
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
      cl22855
      Location:99229
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      154921442..154928620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538830.1XP_006538893.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      See identical proteins and their annotated locations for XP_006538893.1

      Conserved Domains (3) summary
      cd00185
      Location:138201
      TNFRSF; CRD2 [structural motif]
      cd10582
      Location:42142
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
      cl22855
      Location:99229
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    2. XM_011250244.1XP_011248546.1  tumor necrosis factor receptor superfamily member 14 isoform X1

      See identical proteins and their annotated locations for XP_011248546.1

      Related
      ENSMUSP00000151575.1, ENSMUST00000219534.1
      Conserved Domains (3) summary
      cd00185
      Location:138201
      TNFRSF; CRD2 [structural motif]
      cd10582
      Location:42142
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
      cl22855
      Location:99229
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    3. XM_006538833.2XP_006538896.1  tumor necrosis factor receptor superfamily member 14 isoform X4

      Conserved Domains (2) summary
      cd00185
      Location:89148
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
      cd10582
      Location:187
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
    4. XM_006538832.3XP_006538895.1  tumor necrosis factor receptor superfamily member 14 isoform X3

      Conserved Domains (1) summary
      cd10582
      Location:42135
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
    5. XM_006538831.3XP_006538894.1  tumor necrosis factor receptor superfamily member 14 isoform X2

      See identical proteins and their annotated locations for XP_006538894.1

      UniProtKB/TrEMBL
      Q80WM9
      Conserved Domains (3) summary
      cd00185
      Location:138201
      TNFRSF; CRD2 [structural motif]
      cd10582
      Location:42142
      TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
      cl22855
      Location:99229
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
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