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    TSPY1 testis specific protein, Y-linked 1 [ Homo sapiens (human) ]

    Gene ID: 7258, updated on 9-Apr-2017
    Official Symbol
    TSPY1provided by HGNC
    Official Full Name
    testis specific protein, Y-linked 1provided by HGNC
    Primary source
    HGNC:HGNC:12381
    See related
    Ensembl:ENSG00000258992 MIM:480100; Vega:OTTHUMG00000171452
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT78; TSPY; DYS14; pJA923
    Summary
    The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Many functional paralogs and pseudogenes of this gene are present in a cluster in humans, but only a single, nonfunctional orthologous gene is found in mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
    Location:
    Yp11.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) Y NC_000024.10 (9466955..9469756)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (9304564..9307359)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene testis specific protein, Y-linked 3 Neighboring gene family with sequence similarity 197 Y-linked member 5 Neighboring gene family with sequence similarity 197 Y-linked member 4 Neighboring gene testis specific protein, Y-linked 9, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    gonadal mesoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    sex differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    testis-specific Y-encoded protein 1
    Names
    cancer/testis antigen 78

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027958.1 RefSeqGene

      Range
      5001..7795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001197242.2NP_001184171.1  testis-specific Y-encoded protein 1 isoform TSPY-L

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice compared to variant 1, which results in a frameshift. The resulting isoform (TSPY-L) has a shorter and distinct C-terminus compared to isoform TSPY1-S.
      Source sequence(s)
      AC006156
      Consensus CDS
      CCDS76071.1
      UniProtKB/Swiss-Prot
      Q01534
      Related
      ENSP00000389324.3, ENST00000423647.6
      Conserved Domains (1) summary
      cl08298
      Location:103273
      NAP; Nucleosome assembly protein (NAP)
    2. NM_001320964.1NP_001307893.1  testis-specific Y-encoded protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AI002165, BC121113
      UniProtKB/TrEMBL
      A4FUW6
      Conserved Domains (1) summary
      cl08298
      Location:39201
      NAP; Nucleosome assembly protein (NAP)
    3. NM_003308.4NP_003299.2  testis-specific Y-encoded protein 1 isoform TSPY-S

      See identical proteins and their annotated locations for NP_003299.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (TSPY-S).
      Source sequence(s)
      AC006156
      Consensus CDS
      CCDS48205.1
      UniProtKB/Swiss-Prot
      Q01534
      Related
      ENSP00000403304.1, OTTHUMP00000246057, ENST00000451548.5, OTTHUMT00000413463
      Conserved Domains (1) summary
      cl08298
      Location:126288
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p7 Primary Assembly

      Range
      9466955..9469756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017030064.1XP_016885553.1  testis-specific Y-encoded protein 1 isoform X1

    RNA

    1. XR_001756005.1 RNA Sequence

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