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    HDGFRP2 hepatoma-derived growth factor-related protein 2 [ Homo sapiens (human) ]

    Gene ID: 84717, updated on 20-Feb-2017
    Gene symbol
    HDGFRP2
    Gene description
    hepatoma-derived growth factor-related protein 2
    See related
    Ensembl:ENSG00000167674 Vega:OTTHUMG00000182007
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HDGF2; HRP-2; HDGF-2
    Summary
    This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
    Orthologs
    Location:
    19p13.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (4472196..4502220)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4472255..4502223)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985297 Neighboring gene chromatin assembly factor 1 subunit A Neighboring gene microRNA 4746 Neighboring gene UBX domain protein 6 Neighboring gene perilipin 4 Neighboring gene perilipin 5 Neighboring gene leucine rich alpha-2-glycoprotein 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr Hepatoma-derived growth factor 2 (HRP2) restores salt-stripped HIV-1 preintegration complex (PIC) activity in vitro PubMed
    integrase gag-pol Hepatoma-derived growth factor 2 (HRP2) restores salt-stripped HIV-1 preintegration complex (PIC) activity in vitro PubMed
    gag-pol Knockdown of HRP-2 by siRNA in LEDGF/p75-depleted cells reduces integration frequency in transcription units and shifts the integration distribution towards random PubMed
    gag-pol HRP-2 functions as a co-factor of HIV-1 IN in LEDGF/p75-depleted cells. HRP-2 overexpression rescues HIV-1 replication and restored integration in genes to wild-type levels PubMed
    gag-pol Hepatoma-derived growth factor-related protein 2 translocates HIV-1 integrase from the cytoplasm to the nucleus where both proteins co-localize PubMed
    matrix gag Hepatoma-derived growth factor 2 (HRP2) restores salt-stripped HIV-1 preintegration complex (PIC) activity in vitro PubMed
    reverse transcriptase gag-pol Hepatoma-derived growth factor 2 (HRP2) restores salt-stripped HIV-1 preintegration complex (PIC) activity in vitro PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC2641

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    hepatoma-derived growth factor-related protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001520.2NP_001001520.1  hepatoma-derived growth factor-related protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001001520.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AF294267, AL520441, AW054790, HY016231
      Consensus CDS
      CCDS42472.1
      UniProtKB/Swiss-Prot
      Q7Z4V5
      Related
      ENSP00000483345, OTTHUMP00000275780, ENST00000616600, OTTHUMT00000458642
      Conserved Domains (2) summary
      cd05834
      Location:387
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      pfam11467
      Location:472576
      LEDGF; Lens epithelium-derived growth factor (LEDGF)
    2. NM_001348169.1NP_001335098.1  hepatoma-derived growth factor-related protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' exon resulting in a novel 5' UTR and 5' coding region compared to variant 1. The encoded isoform (3) has a longer and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC011498, BU738961, KF573697
    3. NM_032631.3NP_116020.1  hepatoma-derived growth factor-related protein 2 isoform 2

      See identical proteins and their annotated locations for NP_116020.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      AF294267, AL520441, AW054790, BC000755, HY016231
      Consensus CDS
      CCDS59336.1
      UniProtKB/Swiss-Prot
      Q7Z4V5
      Related
      ENSP00000483702, OTTHUMP00000275781, ENST00000621835, OTTHUMT00000458643
      Conserved Domains (2) summary
      cd05834
      Location:387
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      pfam11467
      Location:472576
      LEDGF; Lens epithelium-derived growth factor (LEDGF)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      4472196..4502220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528377.2XP_011526679.1  hepatoma-derived growth factor-related protein 2 isoform X2

      Conserved Domains (2) summary
      pfam11467
      Location:496600
      LEDGF; Lens epithelium-derived growth factor (LEDGF)
      cl02554
      Location:49111
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
    2. XM_011528375.2XP_011526677.1  hepatoma-derived growth factor-related protein 2 isoform X1

      Conserved Domains (2) summary
      pfam11467
      Location:496600
      LEDGF; Lens epithelium-derived growth factor (LEDGF)
      cl02554
      Location:49111
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
    3. XM_011528376.2XP_011526678.1  hepatoma-derived growth factor-related protein 2 isoform X3

      Conserved Domains (2) summary
      pfam11467
      Location:495599
      LEDGF; Lens epithelium-derived growth factor (LEDGF)
      cl02554
      Location:49111
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      4471778..4502393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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