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    OXR1 oxidation resistance 1 [ Homo sapiens (human) ]

    Gene ID: 55074, updated on 22-Apr-2017
    Official Symbol
    OXR1provided by HGNC
    Official Full Name
    oxidation resistance 1provided by HGNC
    Primary source
    HGNC:HGNC:15822
    See related
    Ensembl:ENSG00000164830 MIM:605609; Vega:OTTHUMG00000167682
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TLDC3; Nbla00307
    Orthologs
    Location:
    8q23.1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (106270178..106752694)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (107282406..107764922)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein, FOG family member 2 Neighboring gene ZFPM2 antisense RNA 1 Neighboring gene solute carrier family 16 member 14 pseudogene 1 Neighboring gene uncharacterized LOC105375700 Neighboring gene uncharacterized LOC107986900 Neighboring gene transgelin 2 pseudogene 1 Neighboring gene RNA, U7 small nuclear 84 pseudogene Neighboring gene actin binding Rho activating protein

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ10125, FLJ38829, FLJ40849, FLJ41673, FLJ42450, FLJ45656

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hydroperoxide IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of oxidative stress-induced neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of peptidyl-cysteine S-nitrosylation IEA
    Inferred from Electronic Annotation
    more info
     
    neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    response to oxidative stress NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    oxidation resistance protein 1
    Names
    TBC/LysM-associated domain containing 3
    putative protein product of Nbla00307

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198532.1NP_001185461.1  oxidation resistance protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001185461.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AK296561, BM668428, FN650108
      Consensus CDS
      CCDS56548.1
      UniProtKB/Swiss-Prot
      Q8N573
      Related
      ENSP00000405424.2, OTTHUMP00000274893, ENST00000442977.6, OTTHUMT00000474192
      Conserved Domains (3) summary
      smart00584
      Location:712874
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:72143
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:101143
      LysM; LysM domain
    2. NM_001198533.1NP_001185462.1  oxidation resistance protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001185462.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' sequence, compared to variant 3. The resulting isoform (4) has a distinct and one aa shorter N-terminus, as compared to isoform 3.
      Source sequence(s)
      BM668428, DA232248, FN650108
      Consensus CDS
      CCDS56547.1
      UniProtKB/Swiss-Prot
      Q8N573
      Related
      ENSP00000429205.2, OTTHUMP00000227581, ENST00000517566.6, OTTHUMT00000380410
      Conserved Domains (3) summary
      smart00584
      Location:711873
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:71142
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:100142
      LysM; LysM domain
    3. NM_001198534.1NP_001185463.1  oxidation resistance protein 1 isoform 5

      See identical proteins and their annotated locations for NP_001185463.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks multiple 5' exons and has an alternate 5' exon, compared to variant 3. The resulting isoform (5) has a distinct and much shorter N-terminus, as compared to isoform 3.
      Source sequence(s)
      AB075503, BC032710, BM668428, DC366184, FN650108
      Consensus CDS
      CCDS56549.1
      UniProtKB/Swiss-Prot
      Q8N573
      Related
      ENSP00000297447.6, OTTHUMP00000209769, ENST00000297447.10, OTTHUMT00000343927
      Conserved Domains (1) summary
      smart00584
      Location:81243
      TLDc; domain in TBC and LysM domain containing proteins
    4. NM_001198535.1NP_001185464.1  oxidation resistance protein 1 isoform 6

      See identical proteins and their annotated locations for NP_001185464.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks multiple 5' exons and an internal in-frame exon, and has an alternate 5' exon, compared to variant 3. The resulting isoform (6) has a distinct and much shorter N-terminus and lacks an internal segment, as compared to isoform 3.
      Source sequence(s)
      BM668428, DC366184, FN650108, FN650109
      Consensus CDS
      CCDS56550.1
      UniProtKB/Swiss-Prot
      Q8N573
      Related
      ENSP00000408659.2, OTTHUMP00000209770, ENST00000449762.6, OTTHUMT00000343928
      Conserved Domains (1) summary
      smart00584
      Location:54216
      TLDc; domain in TBC and LysM domain containing proteins
    5. NM_018002.3NP_060472.2  oxidation resistance protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has an alternate 5' sequence and lacks an internal in-frame exon, compared to variant 3. The resulting isoform (1) has a distinct and one aa shorter N-terminus and lacks an internal segment, as compared to isoform 3.
      Source sequence(s)
      AK124441, BC032710, BM668428, DA232248, FN650108
      Consensus CDS
      CCDS47909.1
      UniProtKB/Swiss-Prot
      Q8N573
      Related
      ENSP00000431966.1, OTTHUMP00000227750, ENST00000531443.5, OTTHUMT00000380661
      Conserved Domains (3) summary
      smart00584
      Location:684846
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:71142
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:100142
      LysM; LysM domain
    6. NM_181354.4NP_851999.2  oxidation resistance protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence and lacks an internal in-frame exon, compared to variant 3. The resulting isoform (2) has a distinct and shorter N-terminus and lacks an internal segment, as compared to isoform 3.
      Source sequence(s)
      AC023344, BC032710, BM682193, DA544318
      Consensus CDS
      CCDS6304.2
      UniProtKB/Swiss-Prot
      Q8N573
      Related
      ENSP00000311026.6, OTTHUMP00000209768, ENST00000312046.10, OTTHUMT00000343925
      Conserved Domains (3) summary
      smart00584
      Location:677839
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:93135
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:93135
      LysM; LysM domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      106270178..106752694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013596.1XP_016869085.1  oxidation resistance protein 1 isoform X8

    2. XM_006716595.2XP_006716658.1  oxidation resistance protein 1 isoform X2

      Conserved Domains (3) summary
      smart00584
      Location:685847
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:72143
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:101143
      LysM; LysM domain
    3. XM_017013591.1XP_016869080.1  oxidation resistance protein 1 isoform X4

    4. XM_017013590.1XP_016869079.1  oxidation resistance protein 1 isoform X3

    5. XM_017013597.1XP_016869086.1  oxidation resistance protein 1 isoform X8

    6. XM_017013594.1XP_016869083.1  oxidation resistance protein 1 isoform X7

      UniProtKB/Swiss-Prot
      Q8N573
      Conserved Domains (3) summary
      smart00584
      Location:596758
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:1254
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:1254
      LysM; LysM domain
    7. XM_017013593.1XP_016869082.1  oxidation resistance protein 1 isoform X6

    8. XM_017013598.1XP_016869087.1  oxidation resistance protein 1 isoform X8

    9. XM_017013599.1XP_016869088.1  oxidation resistance protein 1 isoform X9

    10. XM_017013589.1XP_016869078.1  oxidation resistance protein 1 isoform X1

    11. XM_017013595.1XP_016869084.1  oxidation resistance protein 1 isoform X8

    12. XM_017013600.1XP_016869089.1  oxidation resistance protein 1 isoform X9

      Related
      ENSP00000430701.2, OTTHUMP00000229983, ENST00000519415.6, OTTHUMT00000384503
    13. XM_017013592.1XP_016869081.1  oxidation resistance protein 1 isoform X5

    RNA

    1. XR_001745548.1 RNA Sequence

    2. XR_001745546.1 RNA Sequence

    3. XR_001745547.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      107322938..107805369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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