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    SCD5 stearoyl-CoA desaturase 5 [ Homo sapiens (human) ]

    Gene ID: 79966, updated on 8-Apr-2018
    Official Symbol
    SCD5provided by HGNC
    Official Full Name
    stearoyl-CoA desaturase 5provided by HGNC
    Primary source
    HGNC:HGNC:21088
    See related
    Ensembl:ENSG00000145284 MIM:608370; Vega:OTTHUMG00000130293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCD2; SCD4; ACOD4; FADS4; HSCD5
    Summary
    Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in brain (RPKM 129.6), adrenal (RPKM 62.7) and 5 other tissues See more
    Orthologs
    Location:
    4q21.22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (82629537..82798857, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (83550690..83720010, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 11 pseudogene Neighboring gene long intergenic non-protein coding RNA 575 Neighboring gene PQ loop repeat containing 1 pseudogene 2 Neighboring gene microRNA 575 Neighboring gene SEC31 homolog A, COPII coat complex component Neighboring gene THAP9 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 143 Neighboring gene small nucleolar RNA, C/D box 144

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • AMPK signaling pathway, organism-specific biosystem (from KEGG)
      AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • AMPK signaling pathway, conserved biosystem (from KEGG)
      AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • Biosynthesis of unsaturated fatty acids, organism-specific biosystem (from KEGG)
      Biosynthesis of unsaturated fatty acids, organism-specific biosystem
      Biosynthesis of unsaturated fatty acids
    • Biosynthesis of unsaturated fatty acids, conserved biosystem (from KEGG)
      Biosynthesis of unsaturated fatty acids, conserved biosystem
      Biosynthesis of unsaturated fatty acids
    • Fatty Acyl-CoA Biosynthesis, organism-specific biosystem (from REACTOME)
      Fatty Acyl-CoA Biosynthesis, organism-specific biosystemFatty acyl-CoA biosynthesis involves following steps: -Palmitate synthesis catalyzed by Acetyl-CoA carboxylase and Fatty acid synthase-Conversion of palmitic acid to long chain fatty acids and-Conver...
    • Fatty acid metabolism, organism-specific biosystem (from KEGG)
      Fatty acid metabolism, organism-specific biosystem
      Fatty acid metabolism
    • Fatty acid metabolism, conserved biosystem (from KEGG)
      Fatty acid metabolism, conserved biosystem
      Fatty acid metabolism
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • PPAR signaling pathway, organism-specific biosystem (from KEGG)
      PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPAR signaling pathway, conserved biosystem (from KEGG)
      PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • Triglyceride Biosynthesis, organism-specific biosystem (from REACTOME)
      Triglyceride Biosynthesis, organism-specific biosystemThe overall process of triglyceride (triacylglycerol) biosynthesis consists of four biochemical pathways: fatty acyl-CoA biosynthesis, conversion of fatty acyl-CoA to phosphatidic acid, conversion of...
    • oleate biosynthesis, organism-specific biosystem (from BIOCYC)
      oleate biosynthesis, organism-specific biosystem: OLEATE-CPD (oleic acid) is a monounsaturated fatty acid that makes up 55-80% of olive oil (although the free acid may consist only 0.5-2.5%) and 15-20% of grape seed oil and sea buckthorn oil. Ole...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ21032

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stearoyl-CoA 9-desaturase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    stearoyl-CoA 9-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    stearoyl-CoA 9-desaturase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    fatty-acyl-CoA biosynthetic process TAS
    Traceable Author Statement
    more info
     
    monounsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    unsaturated fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    stearoyl-CoA desaturase 5
    Names
    acyl-CoA-desaturase 4
    stearoyl-CoA 9-desaturase
    stearoyl-CoA desaturase 2
    stearoyl-CoA desaturase 4
    NP_001032671.2
    NP_079182.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037582.2NP_001032671.2  stearoyl-CoA desaturase 5 isoform a

      See identical proteins and their annotated locations for NP_001032671.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encoded the longer isoform (A).
      Source sequence(s)
      AF389338, BC048971, CB155881, DB479400, DR763368
      Consensus CDS
      CCDS34024.1
      UniProtKB/Swiss-Prot
      Q86SK9
      UniProtKB/TrEMBL
      Q86UC8
      Related
      ENSP00000316329.4, OTTHUMP00000160803, ENST00000319540.8, OTTHUMT00000252635
      Conserved Domains (2) summary
      cd03505
      Location:71311
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
      pfam00487
      Location:77279
      FA_desaturase; Fatty acid desaturase
    2. NM_024906.2NP_079182.2  stearoyl-CoA desaturase 5 isoform b

      See identical proteins and their annotated locations for NP_079182.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the 3' coding region, compared to variant 1, which result in a protein (isoform B) with a shorter and distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AC073413
      Consensus CDS
      CCDS3595.1
      UniProtKB/Swiss-Prot
      Q86SK9
      Related
      ENSP00000273908.4, OTTHUMP00000160804, ENST00000273908.4, OTTHUMT00000252636
      Conserved Domains (1) summary
      cd03505
      Location:71159
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

      Range
      82629537..82798857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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