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    Chn2 chimerin 2 [ Mus musculus (house mouse) ]

    Gene ID: 69993, updated on 12-Mar-2017
    Official Symbol
    Chn2provided by MGI
    Official Full Name
    chimerin 2provided by MGI
    Primary source
    MGI:MGI:1917243
    See related
    Ensembl:ENSMUSG00000004633 Vega:OTTMUSG00000023143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bch; ARHGAP3; 1700026N20Rik; 4930557O16Rik
    Orthologs
    Location:
    6; 6 B3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (54039932..54301812)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (53989926..54251806)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33716 Neighboring gene carboxypeptidase, vitellogenic-like Neighboring gene RIKEN cDNA 4921529L05 gene Neighboring gene RIKEN cDNA 9530036M11 gene Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene RIKEN cDNA 9130019P16 gene Neighboring gene predicted gene, 34169 Neighboring gene proline rich 15 Neighboring gene WAS/WASL interacting protein family, member 3 Neighboring gene predicted gene, 44026

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    beta-chimaerin
    Names
    Rho GTPase-activating protein 3
    chimerin (chimaerin) 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163640.1NP_001157112.1  beta-chimaerin isoform 2

      See identical proteins and their annotated locations for NP_001157112.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate, upstream transcription initiation site, uses a distinct start codon and contains several additional exons, compared to variant 1. The resulting protein (isoform 2, also referred to as beta2-chimerin) has a much longer and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK131641, BB617538, BB676245, BM935649, BQ175659
      Consensus CDS
      CCDS51778.1
      UniProtKB/TrEMBL
      Q3V2R3
      Related
      ENSMUSP00000035908, OTTMUSP00000026841, ENSMUST00000046856, OTTMUST00000055937
      Conserved Domains (3) summary
      cd10352
      Location:52138
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:275468
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:215267
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    2. NM_001311133.1NP_001298062.1  beta-chimaerin isoform 3

      See identical proteins and their annotated locations for NP_001298062.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation from an alternate start codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC084220, AI848376, AK006398, AK131641
      Consensus CDS
      CCDS80535.1
      UniProtKB/Swiss-Prot
      Q80XD1
      UniProtKB/TrEMBL
      Q3V2R3
      Related
      ENSMUSP00000114476, OTTMUSP00000027016, ENSMUST00000146114, OTTMUST00000056265
      Conserved Domains (2) summary
      cd04372
      Location:89282
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:2981
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    3. NM_001311134.1NP_001298063.1  beta-chimaerin isoform 4

      See identical proteins and their annotated locations for NP_001298063.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon and initiates translation from an alternate start codon, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC084220, AI848376, AK006398, BU583546
      Consensus CDS
      CCDS80536.1
      UniProtKB/Swiss-Prot
      Q80XD1
      UniProtKB/TrEMBL
      Q3TVA5
      Related
      ENSMUSP00000110043, OTTMUSP00000027017, ENSMUST00000114401, OTTMUST00000056266
      Conserved Domains (2) summary
      cd04372
      Location:84277
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:2476
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    4. NM_023543.2NP_076032.2  beta-chimaerin isoform 1

      See identical proteins and their annotated locations for NP_076032.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AK131641, BB676245, BM935649, BQ175659, CX238009
      Consensus CDS
      CCDS20154.1
      UniProtKB/Swiss-Prot
      Q80XD1
      UniProtKB/TrEMBL
      Q3V2R3
      Related
      ENSMUSP00000066078, OTTMUSP00000026860, ENSMUST00000067741, OTTMUST00000055967
      Conserved Domains (2) summary
      cd04372
      Location:139332
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:79131
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      54039932..54301812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506578.3XP_006506641.1  beta-chimaerin isoform X1

      See identical proteins and their annotated locations for XP_006506641.1

      UniProtKB/TrEMBL
      Q3TVA5
      Related
      ENSMUSP00000110044, OTTMUSP00000027018, ENSMUST00000114402, OTTMUST00000056267
      Conserved Domains (2) summary
      cd04372
      Location:84277
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:2476
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
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