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    HACD3 3-hydroxyacyl-CoA dehydratase 3 [ Homo sapiens (human) ]

    Gene ID: 51495, updated on 19-May-2018
    Official Symbol
    HACD3provided by HGNC
    Official Full Name
    3-hydroxyacyl-CoA dehydratase 3provided by HGNC
    Primary source
    HGNC:HGNC:24175
    See related
    Ensembl:ENSG00000074696 MIM:615940; Vega:OTTHUMG00000172658
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BIND1; B-IND1; HSPC121; PTPLAD1
    Expression
    Ubiquitous expression in brain (RPKM 49.9), adrenal (RPKM 46.4) and 25 other tissues See more
    Orthologs
    See HACD3 in Genome Data Viewer
    Location:
    15q22.31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (65530489..65578355)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65822804..65870693)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily DCC subclass member 4 Neighboring gene dipeptidyl peptidase 8 Neighboring gene RNA, U6 small nuclear 19, pseudogene Neighboring gene integrator complex subunit 14 Neighboring gene uncharacterized LOC102723464 Neighboring gene solute carrier family 24 member 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ90376

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    3-hydroxy-arachidoyl-CoA dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    3-hydroxy-behenoyl-CoA dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    3-hydroxy-lignoceroyl-CoA dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    3-hydroxyacyl-CoA dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    3-hydroxyacyl-CoA dehydratase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enzyme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    very-long-chain 3-hydroxyacyl-CoA dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    Rac protein signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    activation of JUN kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    fatty acid elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    fatty acid elongation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation by virus of viral protein levels in host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    very long-chain fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion HDA PubMed 
    integral component of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3
    Names
    butyrate-induced protein 1
    butyrate-induced transcript 1
    protein tyrosine phosphatase-like A domain containing 1
    protein tyrosine phosphatase-like protein PTPLAD1
    protein-tyrosine phosphatase-like A domain-containing protein 1
    very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3
    NP_057479.2
    XP_011519966.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016395.2NP_057479.2  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3

      See identical proteins and their annotated locations for NP_057479.2

      Status: VALIDATED

      Source sequence(s)
      BC019873, BC035508, BC058912, H21635
      Consensus CDS
      CCDS45282.1
      UniProtKB/Swiss-Prot
      Q9P035
      Related
      ENSP00000261875.5, OTTHUMP00000248991, ENST00000261875.9, OTTHUMT00000419739
      Conserved Domains (2) summary
      cd06465
      Location:8115
      p23_hB-ind1_like; p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) ...
      pfam04387
      Location:195355
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

      Range
      65530489..65578355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521664.2XP_011519966.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 isoform X1

      UniProtKB/TrEMBL
      H3BRL8
      Related
      ENSP00000456300.1, OTTHUMP00000249080, ENST00000566074.5
      Conserved Domains (1) summary
      pfam04387
      Location:78238
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA
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