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    ZNF644 zinc finger protein 644 [ Homo sapiens (human) ]

    Gene ID: 84146, updated on 5-Nov-2017
    Official Symbol
    ZNF644provided by HGNC
    Official Full Name
    zinc finger protein 644provided by HGNC
    Primary source
    HGNC:HGNC:29222
    See related
    Ensembl:ENSG00000122482 MIM:614159; Vega:OTTHUMG00000010078
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NatF; MYP21; ZEP-2; BM-005
    Summary
    The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 9.2), endometrium (RPKM 7.6) and 25 other tissues See more
    Orthologs
    Location:
    1p22.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (90915298..91022269, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (91380855..91487812, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378853 Neighboring gene long intergenic non-protein coding RNA 1763 Neighboring gene phosphorylase kinase regulatory subunit alpha 1 pseudogene Neighboring gene ribosomal protein L5 pseudogene 6 Neighboring gene HFM1, ATP dependent DNA helicase homolog Neighboring gene flap structure-specific endonuclease 1 pseudogene 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Myopia 21, autosomal dominant
    MedGen: C3279997 OMIM: 614167 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of the metabolic syndrome in Indian Asian men.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA1221, MGC60165, MGC70410

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    zinc finger protein 644
    Names
    zinc finger motif enhancer binding protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029760.1 RefSeqGene

      Range
      5001..111958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_016620.3NP_057704.2  zinc finger protein 644 isoform 2

      See identical proteins and their annotated locations for NP_057704.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 3 both encode isoform 2.
      Source sequence(s)
      AB033047, BX477299, DA147194
      Consensus CDS
      CCDS732.1
      UniProtKB/Swiss-Prot
      Q9H582
      Related
      ENSP00000340828.5, OTTHUMP00000011765, ENST00000347275.9, OTTHUMT00000027847
    2. NM_032186.4NP_115562.3  zinc finger protein 644 isoform 2

      See identical proteins and their annotated locations for NP_115562.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 3 both encode isoform 2.
      Source sequence(s)
      AB033047, BI760689, BX477299, DB001551
      Consensus CDS
      CCDS732.1
      UniProtKB/Swiss-Prot
      Q9H582
      Related
      ENSP00000354659.5, OTTHUMP00000011766, ENST00000361321.5, OTTHUMT00000027848
    3. NM_201269.2NP_958357.1  zinc finger protein 644 isoform 1

      See identical proteins and their annotated locations for NP_958357.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC132776, BC150177, BX477299, DB001551
      Consensus CDS
      CCDS731.1
      UniProtKB/Swiss-Prot
      Q9H582
      UniProtKB/TrEMBL
      A7E234
      Related
      ENSP00000337008.5, ENST00000337393.9
      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      90915298..91022269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542258.2XP_011540560.1  zinc finger protein 644 isoform X1

      See identical proteins and their annotated locations for XP_011540560.1

      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    2. XM_017002487.1XP_016857976.1  zinc finger protein 644 isoform X1

      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    3. XM_011542259.2XP_011540561.1  zinc finger protein 644 isoform X1

      See identical proteins and their annotated locations for XP_011540561.1

      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    4. XM_005271260.4XP_005271317.1  zinc finger protein 644 isoform X1

      See identical proteins and their annotated locations for XP_005271317.1

      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    5. XM_017002490.1XP_016857979.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      Q9H582
      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    6. XM_017002489.1XP_016857978.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      Q9H582
      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    7. XM_017002494.1XP_016857983.1  zinc finger protein 644 isoform X3

      UniProtKB/Swiss-Prot
      Q9H582
    8. XM_017002493.1XP_016857982.1  zinc finger protein 644 isoform X3

      UniProtKB/Swiss-Prot
      Q9H582
    9. XM_017002488.1XP_016857977.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      Q9H582
      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    10. XM_005271257.4XP_005271314.1  zinc finger protein 644 isoform X1

      See identical proteins and their annotated locations for XP_005271314.1

      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    11. XM_011542260.2XP_011540562.1  zinc finger protein 644 isoform X1

      See identical proteins and their annotated locations for XP_011540562.1

      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    12. XM_017002492.1XP_016857981.1  zinc finger protein 644 isoform X3

      UniProtKB/Swiss-Prot
      Q9H582
    13. XM_017002491.1XP_016857980.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      Q9H582
      Related
      ENSP00000359469.1, OTTHUMP00000011764, ENST00000370440.5, OTTHUMT00000027846
      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    14. XM_011542261.2XP_011540563.1  zinc finger protein 644 isoform X1

      See identical proteins and their annotated locations for XP_011540563.1

      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      91496050..91602984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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