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    Khk ketohexokinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25659, updated on 3-Apr-2018
    Official Symbol
    Khkprovided by RGD
    Official Full Name
    ketohexokinaseprovided by RGD
    Primary source
    RGD:2966
    See related
    Ensembl:ENSRNOG00000008047
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    KETHPRO
    Summary
    an enzyme that catalyses the phosphorylation of fructose to fructose-l-phosphate [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 1105.1) and Liver (RPKM 877.2) See more
    Orthologs
    See Khk in Genome Data Viewer
    Location:
    6q14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26810577..26821013, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (36626192..36636617, complement)

    Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene prolactin regulatory element binding Neighboring gene abhydrolase domain containing 1 Neighboring gene cell growth regulator with EF hand domain 1 Neighboring gene elastin microfibril interfacer 1 Neighboring gene uncharacterized LOC103692571

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ketohexokinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ketohexokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ketohexokinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    carbohydrate catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    fructose metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    fructose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to fructose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to insulin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to sucrose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to zinc ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    ketohexokinase
    Names
    hepatic fructokinase
    NP_114061.1
    XP_006239852.1
    XP_008762729.1
    XP_017449536.1
    XP_017449537.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031855.3NP_114061.1  ketohexokinase

      See identical proteins and their annotated locations for NP_114061.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078752
      UniProtKB/Swiss-Prot
      Q02974
      Related
      ENSRNOP00000046296.3, ENSRNOT00000043572.3
      Conserved Domains (1) summary
      cd01939
      Location:5295
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

      Range
      26810577..26821013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594048.1XP_017449537.1  ketohexokinase isoform X4

    2. XM_006239790.3XP_006239852.1  ketohexokinase isoform X2

      Conserved Domains (1) summary
      cd01939
      Location:5295
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
    3. XM_008764507.2XP_008762729.1  ketohexokinase isoform X1

      Conserved Domains (1) summary
      cd01939
      Location:5302
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
    4. XM_017594047.1XP_017449536.1  ketohexokinase isoform X3

      Conserved Domains (1) summary
      cd01939
      Location:5250
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...

    Alternate Rn_Celera

    Genomic

    1. AC_000074.1 Alternate Rn_Celera

      Range
      24935944..24946180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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