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    Nup98 nucleoporin 98 [ Mus musculus (house mouse) ]

    Gene ID: 269966, updated on 22-Apr-2017
    Official Symbol
    Nup98provided by MGI
    Official Full Name
    nucleoporin 98provided by MGI
    Primary source
    MGI:MGI:109404
    See related
    Ensembl:ENSMUSG00000063550 Vega:OTTMUSG00000061195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nup96; AI849286; 4732457F17
    Orthologs
    Location:
    7 E2; 7 54.71 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (102119400..102210187, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (109282717..109358634, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene ADP-ribosyltransferase 5 Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 10 Neighboring gene predicted gene, 39062 Neighboring gene post-GPI attachment to proteins 2 Neighboring gene ras homolog family member G

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC118567

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleocytoplasmic transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    telomere tethering at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear periphery ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pore cytoplasmic filaments IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pore outer ring ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    nuclear pore complex protein Nup98-Nup96

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287164.1NP_001274093.1  nuclear pore complex protein Nup98-Nup96 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001274093.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC118592, AK028800, BC050911, BC078630
      Consensus CDS
      CCDS85358.1
      UniProtKB/Swiss-Prot
      Q6PFD9
      UniProtKB/TrEMBL
      A0A1B0GSX7
      Related
      ENSMUSP00000148115.1, OTTMUSP00000077545, ENSMUST00000210682.1, OTTMUST00000149426
      Conserved Domains (4) summary
      pfam04096
      Location:740880
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:13331624
      Nup96; Nuclear protein 96
      pfam13634
      Location:25149
      Nucleoporin_FG; Nucleoporin FG repeat region
      pfam16768
      Location:26336
      NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    2. NM_001287165.1NP_001274094.1  nuclear pore complex protein Nup98-Nup96 isoform 3

      See identical proteins and their annotated locations for NP_001274094.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple coding region differences compared to variant 1 and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC118592, BC050911, BC099600
      Consensus CDS
      CCDS85360.1
      UniProtKB/Swiss-Prot
      Q6PFD9
      UniProtKB/TrEMBL
      B2RQL0, Q4FZE7
      Related
      ENSMUSP00000147486.1, OTTMUSP00000077645, ENSMUST00000211235.1, OTTMUST00000149706
      Conserved Domains (2) summary
      pfam04096
      Location:723863
      Nucleoporin2; Nucleoporin autopeptidase
      pfam13634
      Location:69161
      Nucleoporin_FG; Nucleoporin FG repeat region
    3. NM_001287166.1NP_001274095.1  nuclear pore complex protein Nup98-Nup96 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple coding region differences compared to variant 1 and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC118592, AK164402
      Consensus CDS
      CCDS85359.1
      UniProtKB/TrEMBL
      A0A1B0GRB5, Q3TPG3
      Related
      ENSMUSP00000147454.1, OTTMUSP00000077647, ENSMUST00000211022.1, OTTMUST00000149708
      Conserved Domains (2) summary
      pfam04096
      Location:723863
      Nucleoporin2; Nucleoporin autopeptidase
      pfam13634
      Location:69161
      Nucleoporin_FG; Nucleoporin FG repeat region
    4. NM_001287167.1NP_001274096.1  nuclear pore complex protein Nup98-Nup96 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 5 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC118592, AK146491
      Consensus CDS
      CCDS85357.1
      UniProtKB/TrEMBL
      A0A1B0GRA7, Q3UJE5
      Related
      ENSMUSP00000147445.1, OTTMUSP00000077646, ENSMUST00000211005.1, OTTMUST00000149707
      Conserved Domains (2) summary
      pfam04096
      Location:740880
      Nucleoporin2; Nucleoporin autopeptidase
      pfam13634
      Location:69161
      Nucleoporin_FG; Nucleoporin FG repeat region
    5. NM_022979.2NP_075355.1  nuclear pore complex protein Nup98-Nup96 isoform 2

      See identical proteins and their annotated locations for NP_075355.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC118592, BC050911, BC099600
      Consensus CDS
      CCDS21528.1
      UniProtKB/Swiss-Prot
      Q6PFD9
      UniProtKB/TrEMBL
      A0A140T8J8, Q4FZE7
      Related
      ENSMUSP00000068530.5, OTTMUSP00000077644, ENSMUST00000070165.6, OTTMUST00000149705
      Conserved Domains (2) summary
      pfam04096
      Location:740880
      Nucleoporin2; Nucleoporin autopeptidase
      pfam13634
      Location:69161
      Nucleoporin_FG; Nucleoporin FG repeat region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      102119400..102210187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507897.2XP_006507960.1  nuclear pore complex protein Nup98-Nup96 isoform X3

      Conserved Domains (4) summary
      pfam04096
      Location:693833
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:12861577
      Nup96; Nuclear protein 96
      pfam13634
      Location:25149
      Nucleoporin_FG; Nucleoporin FG repeat region
      pfam16768
      Location:26336
      NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    2. XM_006507896.2XP_006507959.1  nuclear pore complex protein Nup98-Nup96 isoform X2

      Conserved Domains (4) summary
      pfam04096
      Location:723863
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:13161607
      Nup96; Nuclear protein 96
      pfam13634
      Location:25149
      Nucleoporin_FG; Nucleoporin FG repeat region
      pfam16768
      Location:26336
      NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    3. XM_006507895.2XP_006507958.1  nuclear pore complex protein Nup98-Nup96 isoform X1

      See identical proteins and their annotated locations for XP_006507958.1

      UniProtKB/TrEMBL
      A0A1B0GSX7
      Conserved Domains (4) summary
      pfam04096
      Location:740880
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:13331624
      Nup96; Nuclear protein 96
      pfam13634
      Location:25149
      Nucleoporin_FG; Nucleoporin FG repeat region
      pfam16768
      Location:26336
      NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
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