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    Slc6a5 solute carrier family 6 (neurotransmitter transporter, glycine), member 5 [ Mus musculus (house mouse) ]

    Gene ID: 104245, updated on 12-Mar-2017
    Official Symbol
    Slc6a5provided by MGI
    Official Full Name
    solute carrier family 6 (neurotransmitter transporter, glycine), member 5provided by MGI
    Primary source
    MGI:MGI:105090
    See related
    Ensembl:ENSMUSG00000039728 Vega:OTTMUSG00000059001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glyt2; prestin
    Orthologs
    Location:
    7; 7 B4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (49906971..49963864)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (57165669..57214863)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene HIV-1 Tat interactive protein 2 Neighboring gene predicted gene, 45986 Neighboring gene protein arginine N-methyltransferase 3 Neighboring gene NEL-like 1 Neighboring gene RIKEN cDNA 4933405O20 gene Neighboring gene NEL-like 1, opposite strand

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Chemically induced (ENU) (1) 
    • Targeted (3)  1 citation

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    glycine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    glycine:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glycine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    neurotransmitter:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    glycine import IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glycine import ISO
    Inferred from Sequence Orthology
    more info
     
    glycine transport ISO
    Inferred from Sequence Orthology
    more info
     
    neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission, glycinergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synaptic transmission, glycinergic ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    sodium- and chloride-dependent glycine transporter 2
    Names
    glyT-2
    glycine transporter 2
    slc6a5
    solute carrier family 6 member 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146013.1NP_001139485.1  sodium- and chloride-dependent glycine transporter 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC138126, BC157997
      UniProtKB/TrEMBL
      B2RQX9, B2RXV9
      Conserved Domains (1) summary
      cd11499
      Location:193789
      SLC6sbd_GlyT2; Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain
    2. NM_148931.3NP_683733.2  sodium- and chloride-dependent glycine transporter 2 isoform b

      See identical proteins and their annotated locations for NP_683733.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) uses an alternate exon at it's 5'-most end that results in the use of an in-frame downstream start codon, compared to variant a, and a protein (isoform b) with a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      BC138126
      Consensus CDS
      CCDS21308.1
      UniProtKB/TrEMBL
      B2RQX9
      Related
      ENSMUSP00000103230, ENSMUST00000107605
      Conserved Domains (1) summary
      cd11499
      Location:185781
      SLC6sbd_GlyT2; Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      49906971..49963864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540546.3XP_006540609.1  sodium- and chloride-dependent glycine transporter 2 isoform X2

      Conserved Domains (1) summary
      cd11499
      Location:208804
      SLC6sbd_GlyT2; Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain
    2. XM_006540549.3XP_006540612.1  sodium- and chloride-dependent glycine transporter 2 isoform X5

      Conserved Domains (1) summary
      cl00456
      Location:1553
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. XM_006540547.1XP_006540610.1  sodium- and chloride-dependent glycine transporter 2 isoform X3

      See identical proteins and their annotated locations for XP_006540610.1

      UniProtKB/TrEMBL
      B2RQX9
      Related
      ENSMUSP00000146917, OTTMUSP00000075425, ENSMUST00000207753, OTTMUST00000144766
      Conserved Domains (1) summary
      cd11499
      Location:185781
      SLC6sbd_GlyT2; Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain
    4. XM_006540545.3XP_006540608.1  sodium- and chloride-dependent glycine transporter 2 isoform X1

      Conserved Domains (1) summary
      cd11499
      Location:225821
      SLC6sbd_GlyT2; Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain
    5. XM_006540548.2XP_006540611.1  sodium- and chloride-dependent glycine transporter 2 isoform X4

      Conserved Domains (1) summary
      cl00456
      Location:58654
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
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