Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Pard3 par-3 family cell polarity regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81918, updated on 31-Oct-2016
    Official Symbol
    Pard3provided by RGD
    Official Full Name
    par-3 family cell polarity regulatorprovided by RGD
    Primary source
    RGD:620374
    See related
    Ensembl:ENSRNOG00000032437
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Par3
    Summary
    may mediate the establishment and maintenance of epithelial cell polarity [RGD, Feb 2006]
    Orthologs
    Location:
    19q12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (60017746..60580628)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (70690939..71249213)

    Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene similar to GABA(A) receptor-associated protein like 2 Neighboring gene high-mobility group (nonhistone chromosomal) protein 1-like 1 Neighboring gene uncharacterized LOC102548266 Neighboring gene 60S ribosomal protein L28 pseudogene Neighboring gene uncharacterized LOC103694361 Neighboring gene uncharacterized LOC102548408 Neighboring gene uncharacterized LOC103694362

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    phosphatidylinositol-3,4,5-trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apical constriction ISO
    Inferred from Sequence Orthology
    more info
     
    bicellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of epithelial cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of epithelial cell apical/basal polarity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    myelination in peripheral nervous system ISO
    Inferred from Sequence Orthology
    more info
     
    myelination in peripheral nervous system ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of actin filament-based process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cellular localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    wound healing, spreading of cells ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Schmidt-Lanterman incisure ISO
    Inferred from Sequence Orthology
    more info
     
    adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    apical junction complex ISO
    Inferred from Sequence Orthology
    more info
     
    apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    bicellular tight junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    internode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    internode region of axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lateral loop ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    spindle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    partitioning defective 3 homolog
    Names
    ASBP
    ASIP
    PARD-3
    atypical PKC isotype-specific-interacting protein
    atypical PKC-specific binding protein
    par-3 (partitioning defective 3) homolog
    three-PDZ containing protein similar to C. elegans PAR3 (partitioning defect)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031235.1NP_112514.1  partitioning defective 3 homolog

      See identical proteins and their annotated locations for NP_112514.1

      Status: PROVISIONAL

      Source sequence(s)
      AB005549
      UniProtKB/Swiss-Prot
      Q9Z340
      Related
      ENSRNOP00000048964, ENSRNOT00000042623
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

      Range
      60017746..60580628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255828.1XP_006255890.1  

      Related
      ENSRNOP00000075058, ENSRNOT00000078559
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    2. XM_006255830.1XP_006255892.1  

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    3. XM_006255833.1XP_006255895.1  

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    4. XM_006255836.1XP_006255898.1  

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    5. XM_006255837.1XP_006255899.1  

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    6. XM_017601365.1XP_017456854.1  

    7. XM_017601367.1XP_017456856.1  

    8. XM_017601366.1XP_017456855.1  

    9. XM_017601369.1XP_017456858.1  

    10. XM_017601370.1XP_017456859.1  

    11. XM_017601371.1XP_017456860.1  

    12. XM_017601368.1XP_017456857.1  

    Alternate Rn_Celera

    Genomic

    1. AC_000087.1 Alternate Rn_Celera

      Range
      54418687..54967349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center