Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Lgr5 leucine rich repeat containing G protein coupled receptor 5 [ Mus musculus (house mouse) ]

    Gene ID: 14160, updated on 25-May-2017
    Official Symbol
    Lgr5provided by MGI
    Official Full Name
    leucine rich repeat containing G protein coupled receptor 5provided by MGI
    Primary source
    MGI:MGI:1341817
    See related
    Ensembl:ENSMUSG00000020140 Vega:OTTMUSG00000020836
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FEX; Gpr49
    Summary
    The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    10; 10 D2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (115450314..115587780, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (114887370..115024836, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46180 Neighboring gene THAP domain containing, apoptosis associated protein 2 Neighboring gene zinc finger, C3H1-type containing Neighboring gene RIKEN cDNA A930009A15 gene Neighboring gene ribosomal protein S3A pseudogene Neighboring gene tetraspanin 8 Neighboring gene predicted gene, 46181

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (1) 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell proliferation involved in renal tubule morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hair follicle development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inner ear development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    leucine-rich repeat-containing G-protein coupled receptor 5
    Names
    G protein-coupled receptor 49
    follicle expressed hormone
    orphan G-protein coupled receptor FEX

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010195.2NP_034325.2  leucine-rich repeat-containing G-protein coupled receptor 5 precursor

      See identical proteins and their annotated locations for NP_034325.2

      Status: REVIEWED

      Source sequence(s)
      AK132387, BM935530
      Consensus CDS
      CCDS24180.1
      UniProtKB/Swiss-Prot
      Q9Z1P4
      Related
      ENSMUSP00000020350.8, OTTMUSP00000022795, ENSMUST00000020350.14, OTTMUST00000049259
      Conserved Domains (6) summary
      smart00013
      Location:3370
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:88386
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:354375
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:6891
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00001
      Location:575820
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      115450314..115587780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center