Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Cacna1g calcium voltage-gated channel subunit alpha1 G [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29717, updated on 22-Apr-2017
    Official Symbol
    Cacna1gprovided by RGD
    Official Full Name
    calcium voltage-gated channel subunit alpha1 Gprovided by RGD
    Primary source
    RGD:68942
    See related
    Ensembl:ENSRNOG00000060528
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    low voltage-activated calcium channel alpha subunit; involved in calcium ion transport in nerve, muscle and edocrine cells [RGD, Feb 2006]
    Orthologs
    Location:
    10q26
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (82129071..82197828, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (81950594..82017885, complement)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 40 Neighboring gene ATP binding cassette subfamily C member 3 Neighboring gene epsin-3-like Neighboring gene spermatogenesis associated 20 Neighboring gene epsin 3

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
      Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
      Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Circadian entrainment, organism-specific biosystem (from KEGG)
      Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Circadian entrainment, conserved biosystem (from KEGG)
      Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, conserved biosystem (from KEGG)
      Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    AV node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    AV node cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    AV node cell to bundle of His cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    AV node cell to bundle of His cell signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    SA node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    SA node cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    SA node cell to atrial cardiac muscle cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    SA node cell to atrial cardiac muscle cell signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    action potential ISO
    Inferred from Sequence Orthology
    more info
     
    artery smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion import IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transport into cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cardiac muscle cell action potential involved in contraction IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle cell action potential involved in contraction ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle cell action potential involved in contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to dexamethasone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    membrane depolarization during AV node cell action potential IEA
    Inferred from Electronic Annotation
    more info
     
    membrane depolarization during AV node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    membrane depolarization during AV node cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane depolarization during SA node cell action potential IEA
    Inferred from Electronic Annotation
    more info
     
    membrane depolarization during SA node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    membrane depolarization during SA node cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane depolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neuronal action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of calcium ion-dependent exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of atrial cardiac muscle cell membrane depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of atrial cardiac muscle cell membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of heart rate by cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of heart rate by cardiac conduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    response to nickel cation IEA
    Inferred from Electronic Annotation
    more info
     
    response to nickel cation ISO
    Inferred from Sequence Orthology
    more info
     
    sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated calcium channel complex IC
    Inferred by Curator
    more info
    PubMed 
    voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated calcium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    voltage-dependent T-type calcium channel subunit alpha-1G
    Names
    calcium channel, voltage-dependent, T type, alpha 1G subunit
    voltage-gated calcium channel subunit alpha Cav3.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308302.1NP_001295231.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AABR07030343, AABR07030345
      Related
      ENSRNOP00000072061.1, ENSRNOT00000092024.1
      Conserved Domains (1) summary
      pfam00520
      Location:761969
      Ion_trans; Ion transport protein
    2. NM_031601.4NP_113789.3  voltage-dependent T-type calcium channel subunit alpha-1G isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AABR07030343, AABR07030345
      Conserved Domains (1) summary
      pfam00520
      Location:761976
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      82129071..82197828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597182.1XP_017452671.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X3

    2. XM_017597191.1XP_017452680.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X21

    3. XM_017597190.1XP_017452679.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X19

    4. XM_017597184.1XP_017452673.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X5

    5. XM_017597185.1XP_017452674.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X6

    6. XM_017597181.1XP_017452670.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X2

    7. XM_017597183.1XP_017452672.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X4

    8. XM_017597187.1XP_017452676.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X9

    9. XM_017597180.1XP_017452669.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X1

    10. XM_017597186.1XP_017452675.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X7

    11. XM_008767993.2XP_008766215.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X18

      Conserved Domains (1) summary
      pfam00520
      Location:761976
      Ion_trans; Ion transport protein
    12. XM_008767988.2XP_008766210.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X12

      Conserved Domains (1) summary
      pfam00520
      Location:761976
      Ion_trans; Ion transport protein
    13. XM_008767992.2XP_008766214.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X16

      Conserved Domains (1) summary
      pfam00520
      Location:761969
      Ion_trans; Ion transport protein
    14. XM_008767990.2XP_008766212.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X14

      Conserved Domains (1) summary
      pfam00520
      Location:761969
      Ion_trans; Ion transport protein
    15. XM_008767986.2XP_008766208.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X10

      Conserved Domains (1) summary
      pfam00520
      Location:761969
      Ion_trans; Ion transport protein
    16. XM_008767991.2XP_008766213.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X15

      Conserved Domains (1) summary
      pfam00520
      Location:761969
      Ion_trans; Ion transport protein
    17. XM_008767987.2XP_008766209.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X11

      Conserved Domains (1) summary
      pfam00520
      Location:761969
      Ion_trans; Ion transport protein
    18. XM_017597188.1XP_017452677.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X13

    19. XM_008767985.2XP_008766207.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X8

      Conserved Domains (1) summary
      pfam00520
      Location:761969
      Ion_trans; Ion transport protein
    20. XM_008768000.2XP_008766222.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X26

      Conserved Domains (1) summary
      pfam00520
      Location:744959
      Ion_trans; Ion transport protein
    21. XM_008768001.2XP_008766223.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X27

      Related
      ENSRNOP00000071940.1, ENSRNOT00000081307.1
      Conserved Domains (1) summary
      pfam00520
      Location:761976
      Ion_trans; Ion transport protein
    22. XM_008767999.2XP_008766221.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X25

      Conserved Domains (1) summary
      pfam00520
      Location:761976
      Ion_trans; Ion transport protein
    23. XM_017597189.1XP_017452678.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X17

    24. XM_008767997.2XP_008766219.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X23

      Conserved Domains (1) summary
      pfam00520
      Location:761976
      Ion_trans; Ion transport protein
    25. XM_008767998.2XP_008766220.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X24

      Conserved Domains (1) summary
      pfam00520
      Location:761969
      Ion_trans; Ion transport protein
    26. XM_008767996.2XP_008766218.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X22

      Conserved Domains (1) summary
      pfam00520
      Location:761969
      Ion_trans; Ion transport protein
    27. XM_008767994.2XP_008766216.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X20

      Conserved Domains (1) summary
      pfam00520
      Location:761969
      Ion_trans; Ion transport protein
    28. XM_017597192.1XP_017452681.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X28

    29. XM_017597193.1XP_017452682.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform X29

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      78143865..78211268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center