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    Dnah1 dynein, axonemal, heavy chain 1 [ Mus musculus (house mouse) ]

    Gene ID: 110084, updated on 22-Apr-2017
    Official Symbol
    Dnah1provided by MGI
    Official Full Name
    dynein, axonemal, heavy chain 1provided by MGI
    Primary source
    MGI:MGI:107721
    See related
    Ensembl:ENSMUSG00000019027
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MDHC7; Dnahc1; B230373P09Rik; E030034C22Rik
    Orthologs
    Location:
    14 B; 14 19.1 cM
    Exon count:
    79
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (31260375..31326068, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (32073561..32137082, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene PHD finger protein 7 Neighboring gene Brca1 associated protein 1 Neighboring gene predicted gene, 35823 Neighboring gene calpain 7 Neighboring gene SH3-domain binding protein 5 (BTK-associated) Neighboring gene predicted gene, 35907

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...

    Homology

    Clone Names

    • MGC37121, DKFZp434A236

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    microtubule motor activity IC
    Inferred by Curator
    more info
    PubMed 
    Process Evidence Code Pubs
    cilium movement involved in cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cilium movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
     
    inner dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    inner dynein arm ISM
    Inferred from Sequence Model
    more info
    PubMed 
    inner dynein arm ISO
    Inferred from Sequence Orthology
    more info
     
    sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    dynein heavy chain 1, axonemal
    Names
    dynein, axon, heavy chain 1
    dynein, axonemal, heavy polypeptide 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033668.1NP_001028840.1  dynein heavy chain 1, axonemal

      Status: VALIDATED

      Source sequence(s)
      AC108416
      Consensus CDS
      CCDS49436.1
      UniProtKB/TrEMBL
      E9Q8T7
      Related
      ENSMUSP00000043281.7, ENSMUST00000048603.7
      Conserved Domains (5) summary
      pfam03028
      Location:35454238
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:10011402
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:28163162
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:31913406
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:15281758
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      31260375..31326068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315799.1XP_017171288.1  dynein heavy chain 1, axonemal isoform X1

      UniProtKB/TrEMBL
      E9Q8T7
      Conserved Domains (5) summary
      pfam03028
      Location:35454238
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:10011402
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:28163162
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:31913406
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:15281758
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_017315798.1XP_017171287.1  dynein heavy chain 1, axonemal isoform X1

      UniProtKB/TrEMBL
      E9Q8T7
      Conserved Domains (5) summary
      pfam03028
      Location:35454238
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:10011402
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:28163162
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:31913406
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:15281758
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_006518426.3XP_006518489.1  dynein heavy chain 1, axonemal isoform X2

      Conserved Domains (5) summary
      pfam03028
      Location:35453972
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:10011402
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:28163162
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:31913406
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:15281758
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    4. XM_006518427.3XP_006518490.1  dynein heavy chain 1, axonemal isoform X3

      Conserved Domains (5) summary
      pfam03028
      Location:35453596
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:10011402
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:28163162
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:31913406
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:15281758
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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