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    Mnat1 menage a trois 1 [ Mus musculus (house mouse) ]

    Gene ID: 17420, updated on 5-Nov-2017
    Official Symbol
    Mnat1provided by MGI
    Official Full Name
    menage a trois 1provided by MGI
    Primary source
    MGI:MGI:106207
    See related
    Ensembl:ENSMUSG00000021103 Vega:OTTMUSG00000047017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P36; MAT1; E130115E11Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.1), limb E14.5 (RPKM 4.4) and 25 other tissues See more
    Orthologs
    Location:
    12; 12 C3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (73112181..73273988)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (74224704..74374975)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene sine oculis-related homeobox 6 Neighboring gene sine oculis-related homeobox 1 Neighboring gene sine oculis-related homeobox 4 Neighboring gene cytochrome c oxidase subunit 7A2, mitochondrial pseudogene Neighboring gene TRM5 tRNA methyltransferase 5 Neighboring gene solute carrier family 38, member 6 Neighboring gene RIKEN cDNA D830013O20 gene Neighboring gene predicted gene, 40442

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to DNA-dependent ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to RNA polymerase II carboxy-terminal domain kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    adult heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    holo TFIIH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    holo TFIIH complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    CDK-activating kinase assembly factor MAT1
    Names
    CDK7/cyclin-H assembly factor
    RING finger protein MAT1
    p35

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008612.2NP_032638.2  CDK-activating kinase assembly factor MAT1

      See identical proteins and their annotated locations for NP_032638.2

      Status: VALIDATED

      Source sequence(s)
      AK155859, AK157721
      Consensus CDS
      CCDS49087.1
      UniProtKB/Swiss-Prot
      P51949
      Related
      ENSMUSP00000021523.6, OTTMUSP00000067003, ENSMUST00000021523.6, OTTMUST00000121788
      Conserved Domains (2) summary
      TIGR00570
      Location:1308
      cdk7; CDK-activating kinase assembly factor MAT1
      cl17238
      Location:350
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      73112181..73273988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244008.2XP_011242310.1  CDK-activating kinase assembly factor MAT1 isoform X1

      See identical proteins and their annotated locations for XP_011242310.1

      Conserved Domains (1) summary
      TIGR00570
      Location:1187
      cdk7; CDK-activating kinase assembly factor MAT1
    2. XM_006515526.2XP_006515589.1  CDK-activating kinase assembly factor MAT1 isoform X1

      See identical proteins and their annotated locations for XP_006515589.1

      Conserved Domains (1) summary
      TIGR00570
      Location:1187
      cdk7; CDK-activating kinase assembly factor MAT1
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