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    TWSG1 twisted gastrulation BMP signaling modulator 1 [ Homo sapiens (human) ]

    Gene ID: 57045, updated on 7-May-2017
    Official Symbol
    TWSG1provided by HGNC
    Official Full Name
    twisted gastrulation BMP signaling modulator 1provided by HGNC
    Primary source
    HGNC:HGNC:12429
    See related
    Ensembl:ENSG00000128791 MIM:605049; Vega:OTTHUMG00000131597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TSG
    Orthologs
    Location:
    18p11.22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 18 NC_000018.10 (9334767..9402420)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (9334765..9402424)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 12 Neighboring gene uncharacterized LOC107985188 Neighboring gene uncharacterized LOC102724397 Neighboring gene uncharacterized LOC105371980 Neighboring gene ralA binding protein 1 Neighboring gene RNA, U2 small nuclear 27, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
      Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transforming growth factor beta binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    camera-type eye development IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    mesoderm formation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of CD4-positive, alpha-beta T cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    ossification IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of pathway-restricted SMAD protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    salivary gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    twisted gastrulation protein homolog 1
    Names
    twisted gastrulation homolog 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020648.5NP_065699.1  twisted gastrulation protein homolog 1 precursor

      See identical proteins and their annotated locations for NP_065699.1

      Status: VALIDATED

      Source sequence(s)
      AF294628, AI742025, BC020490, BU632669, DA735800
      Consensus CDS
      CCDS11844.1
      UniProtKB/Swiss-Prot
      Q9GZX9
      Related
      ENSP00000262120.5, OTTHUMP00000162352, ENST00000262120.9, OTTHUMT00000254480
      Conserved Domains (1) summary
      pfam04668
      Location:88222
      Tsg; Twisted gastrulation (Tsg) protein conserved region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p7 Primary Assembly

      Range
      9334767..9402420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018929.2 Alternate CHM1_1.1

      Range
      9334596..9402161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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