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    TRO trophinin [ Homo sapiens (human) ]

    Gene ID: 7216, updated on 23-Nov-2017
    Official Symbol
    TROprovided by HGNC
    Official Full Name
    trophininprovided by HGNC
    Primary source
    HGNC:HGNC:12326
    See related
    Ensembl:ENSG00000067445 MIM:300132; Vega:OTTHUMG00000021640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAGED3; MAGE-d3
    Summary
    This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in cancer formation. This gene is located near several other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
    Expression
    Broad expression in ovary (RPKM 9.7), brain (RPKM 9.7) and 20 other tissues See more
    Orthologs
    Location:
    Xp11.21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) X NC_000023.11 (54920563..54931436)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (54946996..54957864)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene inter-alpha-trypsin inhibitor heavy chain family member 6 Neighboring gene MAGE family member D2 Neighboring gene small nucleolar RNA, H/ACA box 11 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA1114

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    embryo implantation TAS
    Traceable Author Statement
    more info
    PubMed 
    homophilic cell adhesion via plasma membrane adhesion molecules TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    trophinin
    Names
    MAGE superfamily protein
    MAGE-D3 antigen
    magphinin
    melanoma antigen, family D, 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012806.1 RefSeqGene

      Range
      4748..15616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001039705.2NP_001034794.1  trophinin isoform 5

      See identical proteins and their annotated locations for NP_001034794.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) represents the longest transcript and encodes the longest isoform (5).
      Source sequence(s)
      AB029037, AF349719, DB177388
      Consensus CDS
      CCDS43959.1
      UniProtKB/Swiss-Prot
      Q12816
      UniProtKB/TrEMBL
      Q9BX91
      Related
      ENSP00000173898.7, OTTHUMP00000023387, ENST00000173898.11, OTTHUMT00000056837
      Conserved Domains (2) summary
      COG1357
      Location:9741183
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      pfam01454
      Location:451611
      MAGE; MAGE family
    2. NM_001271183.1NP_001258112.1  trophinin isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate downstream in-frame start codon, compared to variant 6. The encoded isoform (6) has a shorter N-terminus, compared to isoform 5.
      Source sequence(s)
      AB029037, AF349719, AK296329, DB177388
      Consensus CDS
      CCDS59529.1
      UniProtKB/Swiss-Prot
      Q12816
      UniProtKB/TrEMBL
      B4DK08, Q9BX91
      Related
      ENSP00000405126.2, ENST00000420798.6
      Conserved Domains (2) summary
      pfam01454
      Location:13142
      MAGE; MAGE family
      pfam15847
      Location:718955
      Loricrin; Major keratinocyte cell envelope protein
    3. NM_001271184.1NP_001258113.1  trophinin isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and lacks an alternate exon in the 5' coding region, compared to variant 6. The encoded isoform (7) is shorter than isoform 5.
      Source sequence(s)
      AF349719, AK225841, DA128814
      Consensus CDS
      CCDS59528.1
      UniProtKB/TrEMBL
      Q9BX91
      Related
      ENSP00000364181.2, OTTHUMP00000180628, ENST00000375041.6, OTTHUMT00000280583
      Conserved Domains (2) summary
      COG1357
      Location:577786
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      pfam01454
      Location:54214
      MAGE; MAGE family
    4. NM_016157.3NP_057241.2  trophinin isoform 2

      See identical proteins and their annotated locations for NP_057241.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and lacks a portion of the 3' coding region, which results in a frameshift, compared to variant 6. The encoding isoform (2, also known as magphinin beta) is shorter and has a distinct C-terminus, compared to isoform 5.
      Source sequence(s)
      AF349719, AK027489, DB177388
      Consensus CDS
      CCDS43958.1
      UniProtKB/Swiss-Prot
      Q12816
      UniProtKB/TrEMBL
      A0A024R9X0, Q9BX91
      Related
      ENSP00000318278.8, OTTHUMP00000180636, ENST00000319167.12, OTTHUMT00000280591
      Conserved Domains (1) summary
      pfam01454
      Location:451611
      MAGE; MAGE family
    5. NM_177556.2NP_808224.1  trophinin isoform 2

      See identical proteins and their annotated locations for NP_808224.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' and 3' UTRs, and lacks a portion of the 3' coding region, which results in a frameshift, compared to variant 6. The encoded isoform (2, also known as magphinin beta) is shorter and has a distinct C-terminus, compared to isoform 5.
      Source sequence(s)
      AF349720, AK225841, DB177388
      Consensus CDS
      CCDS43958.1
      UniProtKB/Swiss-Prot
      Q12816
      UniProtKB/TrEMBL
      A0A024R9X0, Q9BX90
      Related
      ENSP00000364162.4, OTTHUMP00000180629, ENST00000375022.8, OTTHUMT00000280584
      Conserved Domains (1) summary
      pfam01454
      Location:451611
      MAGE; MAGE family
    6. NM_177557.2NP_808225.1  trophinin isoform 4

      See identical proteins and their annotated locations for NP_808225.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks an alternate exon in the 5' coding region, and lacks a portion of the 3' coding region, compared to variant 6. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 5.
      Source sequence(s)
      AF349722, AK225841, DB177388
      Consensus CDS
      CCDS59527.1
      UniProtKB/Swiss-Prot
      Q12816
      UniProtKB/TrEMBL
      Q9BX88
      Related
      ENSP00000382641.1, OTTHUMP00000180630, ENST00000399736.5, OTTHUMT00000280585
      Conserved Domains (1) summary
      pfam01454
      Location:54214
      MAGE; MAGE family

    RNA

    1. NR_073148.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternate splice site near the 5' end, and has an alternate 3' exon structure, compared to variant 6. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 6, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF349719, AK225841, DB177388
      Related
      ENST00000445561.5, OTTHUMT00000056830
    2. NR_073149.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate splice site near the 5' end, lacks an internal exon, and has an alternate 3' exon structure, compared to variant 6. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 6, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF349720, AF349721, DB177388
      Related
      ENST00000622017.4

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p7 Primary Assembly

      Range
      54920563..54931436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006724600.2XP_006724663.1  trophinin isoform X1

      See identical proteins and their annotated locations for XP_006724663.1

      UniProtKB/Swiss-Prot
      Q12816
      Conserved Domains (2) summary
      COG1357
      Location:9741183
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      pfam01454
      Location:451611
      MAGE; MAGE family
    2. XM_011530809.1XP_011529111.1  trophinin isoform X1

      See identical proteins and their annotated locations for XP_011529111.1

      UniProtKB/Swiss-Prot
      Q12816
      Conserved Domains (2) summary
      COG1357
      Location:9741183
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      pfam01454
      Location:451611
      MAGE; MAGE family
    3. XM_017029769.1XP_016885258.1  trophinin isoform X3

      UniProtKB/Swiss-Prot
      Q12816
      UniProtKB/TrEMBL
      A0A024R9X0
      Conserved Domains (1) summary
      pfam01454
      Location:451611
      MAGE; MAGE family
    4. XM_017029773.1XP_016885262.1  trophinin isoform X4

    5. XM_017029768.1XP_016885257.1  trophinin isoform X2

      Conserved Domains (2) summary
      COG1357
      Location:9301139
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      pfam01454
      Location:407567
      MAGE; MAGE family
    6. XM_017029772.1XP_016885261.1  trophinin isoform X4

    7. XM_011530808.1XP_011529110.1  trophinin isoform X1

      See identical proteins and their annotated locations for XP_011529110.1

      UniProtKB/Swiss-Prot
      Q12816
      Conserved Domains (2) summary
      COG1357
      Location:9741183
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      pfam01454
      Location:451611
      MAGE; MAGE family
    8. XM_017029770.1XP_016885259.1  trophinin isoform X3

      UniProtKB/Swiss-Prot
      Q12816
      UniProtKB/TrEMBL
      A0A024R9X0
      Conserved Domains (1) summary
      pfam01454
      Location:451611
      MAGE; MAGE family
    9. XM_011530812.1XP_011529114.1  trophinin isoform X1

      See identical proteins and their annotated locations for XP_011529114.1

      UniProtKB/Swiss-Prot
      Q12816
      Conserved Domains (2) summary
      COG1357
      Location:9741183
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      pfam01454
      Location:451611
      MAGE; MAGE family
    10. XM_011530814.1XP_011529116.1  trophinin isoform X2

      See identical proteins and their annotated locations for XP_011529116.1

      Conserved Domains (2) summary
      COG1357
      Location:9301139
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      pfam01454
      Location:407567
      MAGE; MAGE family
    11. XM_011530813.1XP_011529115.1  trophinin isoform X1

      See identical proteins and their annotated locations for XP_011529115.1

      UniProtKB/Swiss-Prot
      Q12816
      Conserved Domains (2) summary
      COG1357
      Location:9741183
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      pfam01454
      Location:451611
      MAGE; MAGE family
    12. XM_017029767.1XP_016885256.1  trophinin isoform X1

      UniProtKB/Swiss-Prot
      Q12816
      Conserved Domains (2) summary
      COG1357
      Location:9741183
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      pfam01454
      Location:451611
      MAGE; MAGE family
    13. XM_011530811.2XP_011529113.1  trophinin isoform X1

      See identical proteins and their annotated locations for XP_011529113.1

      UniProtKB/Swiss-Prot
      Q12816
      Conserved Domains (2) summary
      COG1357
      Location:9741183
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      pfam01454
      Location:451611
      MAGE; MAGE family
    14. XM_017029771.1XP_016885260.1  trophinin isoform X3

      UniProtKB/Swiss-Prot
      Q12816
      UniProtKB/TrEMBL
      A0A024R9X0
      Conserved Domains (1) summary
      pfam01454
      Location:451611
      MAGE; MAGE family

    RNA

    1. XR_001755720.1 RNA Sequence

    2. XR_001755721.1 RNA Sequence

    3. XR_001755722.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018934.2 Alternate CHM1_1.1

      Range
      54937045..54947913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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