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    Vrk1 vaccinia related kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 22367, updated on 9-Jul-2017
    Official Symbol
    Vrk1provided by MGI
    Official Full Name
    vaccinia related kinase 1provided by MGI
    Primary source
    MGI:MGI:1261847
    See related
    Ensembl:ENSMUSG00000021115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    51PK
    Orthologs
    Location:
    12; 12 E-F1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (106010163..106078318)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (107248473..107315620)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 19554 Neighboring gene predicted gene, 32370 Neighboring gene predicted gene, 46377 Neighboring gene predicted gene, 46378 Neighboring gene predicted gene, 32723 Neighboring gene predicted gene, 32635

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (3) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone kinase activity (H3-S10 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    histone kinase activity (H3-T3 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleosomal histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Golgi disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3-S10 phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-T3 phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    Golgi stack ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    serine/threonine-protein kinase VRK1
    Names
    serine/threonine-protein kinase 51PK
    NP_001025014.1
    NP_001025015.1
    NP_035835.1
    XP_006515872.1
    XP_006515873.1
    XP_006515874.1
    XP_006515875.1
    XP_011242405.1
    XP_011242406.1
    XP_017170534.1
    XP_017170535.1
    XP_017170536.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029843.1NP_001025014.1  serine/threonine-protein kinase VRK1 isoform b

      See identical proteins and their annotated locations for NP_001025014.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AK032344, BY130767
      Consensus CDS
      CCDS26157.1
      UniProtKB/Swiss-Prot
      Q80X41
      UniProtKB/TrEMBL
      Q3UWH3
      Related
      ENSMUSP00000082101.4, ENSMUST00000085026.11
      Conserved Domains (2) summary
      smart00220
      Location:37293
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    2. NM_001029844.1NP_001025015.1  serine/threonine-protein kinase VRK1 isoform c

      See identical proteins and their annotated locations for NP_001025015.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (c) lacks an internal segment in the C-terminal region, compared to isoform a.
      Source sequence(s)
      AK032344, BY130767
      Consensus CDS
      CCDS26158.1
      UniProtKB/Swiss-Prot
      Q80X41
      Related
      ENSMUSP00000071922.5, ENSMUST00000072040.6
      Conserved Domains (2) summary
      smart00220
      Location:37293
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    3. NM_011705.3NP_035835.1  serine/threonine-protein kinase VRK1 isoform a

      See identical proteins and their annotated locations for NP_035835.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK032344, BB749810, BY130767
      Consensus CDS
      CCDS36551.1
      UniProtKB/Swiss-Prot
      Q80X41
      Related
      ENSMUSP00000021539.8, ENSMUST00000021539.15
      Conserved Domains (2) summary
      smart00220
      Location:37293
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      106010163..106078318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515810.3XP_006515873.1  serine/threonine-protein kinase VRK1 isoform X2

      See identical proteins and their annotated locations for XP_006515873.1

      UniProtKB/Swiss-Prot
      Q80X41
      Conserved Domains (2) summary
      smart00220
      Location:37293
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    2. XM_006515811.3XP_006515874.1  serine/threonine-protein kinase VRK1 isoform X2

      See identical proteins and their annotated locations for XP_006515874.1

      UniProtKB/Swiss-Prot
      Q80X41
      Conserved Domains (2) summary
      smart00220
      Location:37293
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    3. XM_006515809.2XP_006515872.1  serine/threonine-protein kinase VRK1 isoform X2

      See identical proteins and their annotated locations for XP_006515872.1

      UniProtKB/Swiss-Prot
      Q80X41
      Conserved Domains (2) summary
      smart00220
      Location:37293
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    4. XM_017315046.1XP_017170535.1  serine/threonine-protein kinase VRK1 isoform X4

      UniProtKB/Swiss-Prot
      Q80X41
      Related
      ENSMUSP00000152721.1, ENSMUST00000221312.1
      Conserved Domains (2) summary
      smart00220
      Location:37293
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    5. XM_006515812.2XP_006515875.1  serine/threonine-protein kinase VRK1 isoform X2

      See identical proteins and their annotated locations for XP_006515875.1

      UniProtKB/Swiss-Prot
      Q80X41
      Related
      ENSMUSP00000152109.1, ENSMUST00000220629.1
      Conserved Domains (2) summary
      smart00220
      Location:37293
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    6. XM_017315045.1XP_017170534.1  serine/threonine-protein kinase VRK1 isoform X1

    7. XM_011244104.2XP_011242406.1  serine/threonine-protein kinase VRK1 isoform X6

      Conserved Domains (2) summary
      COG0515
      Location:7148
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cl21453
      Location:1198
      PKc_like; Protein Kinases, catalytic domain
    8. XM_017315047.1XP_017170536.1  serine/threonine-protein kinase VRK1 isoform X5

    9. XM_011244103.1XP_011242405.1  serine/threonine-protein kinase VRK1 isoform X3

      Conserved Domains (2) summary
      smart00220
      Location:37293
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
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