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    Abi2 abl-interactor 2 [ Mus musculus (house mouse) ]

    Gene ID: 329165, updated on 22-Apr-2017
    Official Symbol
    Abi2provided by MGI
    Official Full Name
    abl-interactor 2provided by MGI
    Primary source
    MGI:MGI:106913
    See related
    Ensembl:ENSMUSG00000026782 Vega:OTTMUSG00000047318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI839867; C130078H13; 8430425M24Rik
    Orthologs
    Location:
    1; 1 C2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (60408998..60481945)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (60466642..60538002)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene neurobeachin like 1 Neighboring gene cytochrome P450, family 20, subfamily a, polypeptide 1 Neighboring gene Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Neighboring gene protein transport protein Sec61 subunit gamma Neighboring gene predicted gene 11578

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC90836, MGC90855

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to Rac GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    actin polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    movement of cell or subcellular component ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    SCAR complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    abl interactor 2
    Names
    abelson interactor 2
    abi-2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198570.1NP_001185499.1  abl interactor 2 isoform 1

      See identical proteins and their annotated locations for NP_001185499.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AW492268, BC056345, BC079646, BY135717
      Consensus CDS
      CCDS78593.1
      UniProtKB/Swiss-Prot
      P62484
      UniProtKB/TrEMBL
      Q6AXD2
      Related
      ENSMUSP00000140274.1, OTTMUSP00000067146, ENSMUST00000188618.6, OTTMUST00000122374
      Conserved Domains (2) summary
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:452486
      SH3; Src Homology 3 domain superfamily
    2. NM_001198571.1NP_001185500.1  abl interactor 2 isoform 2

      See identical proteins and their annotated locations for NP_001185500.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AW492268, BC056345, BC079545, BY135717
      Consensus CDS
      CCDS78594.1
      UniProtKB/Swiss-Prot
      P62484
      UniProtKB/TrEMBL
      Q6AXH6
      Related
      ENSMUSP00000141068.1, OTTMUSP00000067147, ENSMUST00000189980.6, OTTMUST00000122375
      Conserved Domains (2) summary
      cd11972
      Location:419479
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
    3. NM_198127.2NP_937760.1  abl interactor 2 isoform 3

      See identical proteins and their annotated locations for NP_937760.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AW492268, BC056345, BY135717
      Consensus CDS
      CCDS14991.1
      UniProtKB/Swiss-Prot
      P62484
      Related
      ENSMUSP00000058754.8, OTTMUSP00000067141, ENSMUST00000052332.14, OTTMUST00000122320
      Conserved Domains (2) summary
      cd11972
      Location:385445
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93163
      Abi_HHR; Abl-interactor HHR

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      60408998..60481945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496075.3XP_006496138.1  abl interactor 2 isoform X1

      Conserved Domains (2) summary
      cd11972
      Location:481541
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
    2. XM_006496080.3XP_006496143.1  abl interactor 2 isoform X10

      Conserved Domains (2) summary
      cd11972
      Location:420480
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
    3. XM_006496085.3XP_006496148.1  abl interactor 2 isoform X15

      Conserved Domains (2) summary
      cd11972
      Location:391451
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
    4. XM_017321240.1XP_017176729.1  abl interactor 2 isoform X2

    5. XM_017321244.1XP_017176733.1  abl interactor 2 isoform X5

    6. XM_017321250.1XP_017176739.1  abl interactor 2 isoform X17

    7. XM_011238539.2XP_011236841.1  abl interactor 2 isoform X9

      Conserved Domains (3) summary
      cd11972
      Location:431491
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam06752
      Location:238320
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
    8. XM_006496076.3XP_006496139.1  abl interactor 2 isoform X3

      Conserved Domains (2) summary
      cd11972
      Location:475535
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93163
      Abi_HHR; Abl-interactor HHR
    9. XM_006496078.3XP_006496141.1  abl interactor 2 isoform X6

      Conserved Domains (3) summary
      cd11972
      Location:446506
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam06752
      Location:282364
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam07815
      Location:93163
      Abi_HHR; Abl-interactor HHR
    10. XM_006496081.3XP_006496144.1  abl interactor 2 isoform X11

      UniProtKB/TrEMBL
      A0A087WPP8
      Related
      ENSMUSP00000139867.1, OTTMUSP00000067149, ENSMUST00000187709.6, OTTMUST00000122378
      Conserved Domains (2) summary
      cd11972
      Location:414474
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93163
      Abi_HHR; Abl-interactor HHR
    11. XM_017321245.1XP_017176734.1  abl interactor 2 isoform X7

    12. XM_006496084.3XP_006496147.1  abl interactor 2 isoform X14

      UniProtKB/TrEMBL
      A0A087WRS3
      Related
      ENSMUSP00000140750.1, OTTMUSP00000067145, ENSMUST00000188594.6, OTTMUST00000122373
      Conserved Domains (3) summary
      cd11972
      Location:397457
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam06752
      Location:233315
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam07815
      Location:93163
      Abi_HHR; Abl-interactor HHR
    13. XM_017321249.1XP_017176738.1  abl interactor 2 isoform X16

    14. XM_017321247.1XP_017176736.1  abl interactor 2 isoform X13

    15. XM_006496079.3XP_006496142.1  abl interactor 2 isoform X8

      Conserved Domains (3) summary
      cd11972
      Location:432492
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam06752
      Location:239321
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
    16. XM_017321246.1XP_017176735.1  abl interactor 2 isoform X12

    17. XM_006496077.3XP_006496140.1  abl interactor 2 isoform X4

      Conserved Domains (3) summary
      cd11972
      Location:452512
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam06752
      Location:288370
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
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