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    Sema7a sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A [ Mus musculus (house mouse) ]

    Gene ID: 20361, updated on 25-May-2017
    Official Symbol
    Sema7aprovided by MGI
    Official Full Name
    sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7Aprovided by MGI
    Primary source
    MGI:MGI:1306826
    See related
    Ensembl:ENSMUSG00000038264 Vega:OTTMUSG00000063232
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Semal; CDw108; H-Sema-L; M-Sema-L; 2900057C09Rik
    Orthologs
    Location:
    9; 9 B
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (57940135..57962865)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (57787942..57810672)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene meiotic nuclear divisions 1 homolog pseudogene Neighboring gene ubiquitin-like 7 (bone marrow stromal cell-derived) Neighboring gene cytochrome P450, family 11, subfamily a, polypeptide 1 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 pseudogene Neighboring gene coiled-coil domain containing 33 Neighboring gene predicted gene 16130

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    neuropilin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    axon extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    olfactory lobe development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    olfactory lobe development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macrophage cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    semaphorin-7A
    Names
    H-Sema K1
    Semaphorin K1
    sema K1
    sema L
    semaphorin-K1
    semaphorin-L

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011352.2NP_035482.1  semaphorin-7A precursor

      See identical proteins and their annotated locations for NP_035482.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057875
      Consensus CDS
      CCDS23235.1
      UniProtKB/Swiss-Prot
      Q9QUR8
      Related
      ENSMUSP00000042211.7, OTTMUSP00000079645, ENSMUST00000043059.8, OTTMUST00000153986
      Conserved Domains (3) summary
      cd11243
      Location:70489
      Sema_7A; The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108)
      pfam01437
      Location:491518
      PSI; Plexin repeat
      cl11960
      Location:547617
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      57940135..57962865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510889.2XP_006510952.1  semaphorin-7A isoform X1

      See identical proteins and their annotated locations for XP_006510952.1

      Conserved Domains (3) summary
      pfam01437
      Location:333360
      PSI; Plexin repeat
      cl11960
      Location:389459
      Ig; Immunoglobulin domain
      cl15693
      Location:2331
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    2. XM_006510888.3XP_006510951.1  semaphorin-7A isoform X1

      See identical proteins and their annotated locations for XP_006510951.1

      Conserved Domains (3) summary
      pfam01437
      Location:333360
      PSI; Plexin repeat
      cl11960
      Location:389459
      Ig; Immunoglobulin domain
      cl15693
      Location:2331
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
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