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    Pank4 pantothenate kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 269614, updated on 5-Nov-2017
    Official Symbol
    Pank4provided by MGI
    Official Full Name
    pantothenate kinase 4provided by MGI
    Primary source
    MGI:MGI:2387466
    See related
    Ensembl:ENSMUSG00000029056 Vega:OTTMUSG00000010467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R75150; D030031I12Rik
    Orthologs
    Location:
    4; 4 E2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (154964123..154980940)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (154338242..154355047)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) Neighboring gene predicted gene, 42363 Neighboring gene hes family bHLH transcription factor 5 Neighboring gene phospholipase C, eta 2 Neighboring gene peroxisomal biogenesis factor 10

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    pantothenate kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    pantothenate kinase 4
    Names
    pantothenic acid kinase 4
    NP_001292733.1
    NP_766578.2
    XP_017175735.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305804.1NP_001292733.1  pantothenate kinase 4 isoform 1

      See identical proteins and their annotated locations for NP_001292733.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK039866, AK050894, BC050089, BX004788
      Consensus CDS
      CCDS84834.1
      UniProtKB/Swiss-Prot
      Q80YV4
      Related
      ENSMUSP00000064330.4, OTTMUSP00000011212, ENSMUST00000070953.10, OTTMUST00000024367
      Conserved Domains (3) summary
      PLN02902
      Location:17820
      PLN02902; pantothenate kinase
      pfam01937
      Location:451807
      DUF89; Protein of unknown function DUF89
      pfam03630
      Location:37364
      Fumble; Fumble
    2. NM_172990.5NP_766578.2  pantothenate kinase 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AK039866, AK050894, BC050089, BX004788
      Consensus CDS
      CCDS19019.1
      UniProtKB/Swiss-Prot
      Q80YV4
      Related
      ENSMUSP00000030931.4, OTTMUSP00000011211, ENSMUST00000030931.10, OTTMUST00000024366
      Conserved Domains (3) summary
      PLN02902
      Location:17773
      PLN02902; pantothenate kinase
      pfam01937
      Location:451760
      DUF89; Protein of unknown function DUF89
      pfam03630
      Location:37364
      Fumble; Fumble

    RNA

    1. NR_131230.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK039866, AK050894, BC050089, BX004788, W87071
      Related
      ENSMUST00000148934.7, OTTMUST00000024368

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      154964123..154980940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320246.1XP_017175735.1  pantothenate kinase 4 isoform X1

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