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    Ap2m1 adaptor-related protein complex 2, mu 1 subunit [ Mus musculus (house mouse) ]

    Gene ID: 11773, updated on 22-Apr-2017
    Official Symbol
    Ap2m1provided by MGI
    Official Full Name
    adaptor-related protein complex 2, mu 1 subunitprovided by MGI
    Primary source
    MGI:MGI:1298405
    See related
    Ensembl:ENSMUSG00000022841 Vega:OTTMUSG00000025969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes the mu subunit of the clathrin adaptor protein complex AP-2. It mediates sorting of cargo proteins harboring Y-X-X-Phi motifs into clathrin-coated vesicles. Alternate splicing of this gene results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2, 8 and 19. [provided by RefSeq, Dec 2014]
    Orthologs
    Location:
    16; 16 A3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (20535480..20544909)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (20535577..20544126)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2B, subunit 5 epsilon Neighboring gene dishevelled segment polarity protein 3 Neighboring gene mitochondrial ribosomal protein S18B pseudogene Neighboring gene ATP-binding cassette, sub-family F (GCN20), member 3

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC102136

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    disordered domain specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular protein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle budding from presynaptic endocytic zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    AP-2 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule TAS
    Traceable Author Statement
    more info
    PubMed 
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    AP-2 complex subunit mu
    Names
    AP-2 mu chain
    adapter-related protein complex 2 mu subunit
    adaptor protein complex AP-2 subunit mu
    adaptor protein complex AP-2, mu1
    adaptor-related protein complex 2 subunit mu
    adaptor-related protein complex AP-2, mu1
    clathrin assembly protein complex 2 medium chain
    clathrin assembly protein complex 2 mu medium chain
    clathrin coat assembly protein AP50
    clathrin coat-associated protein AP50
    clathrin-associated AP-2
    mu2-adaptin
    plasma membrane adaptor AP-2 50 kDa protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302970.1NP_001289899.1  AP-2 complex subunit mu isoform 2

      See identical proteins and their annotated locations for NP_001289899.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK141862, AK146517, AK172889
      Consensus CDS
      CCDS79436.1
      UniProtKB/TrEMBL
      Q3TWV4, Q5FWI9, Q6A0C9
      Related
      ENSMUSP00000087477.6, OTTMUSP00000031780, ENSMUST00000090023.12, OTTMUST00000064079
      Conserved Domains (1) summary
      cd09251
      Location:166432
      AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
    2. NM_009679.3NP_033809.1  AP-2 complex subunit mu isoform 1

      See identical proteins and their annotated locations for NP_033809.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK141862, AK146517
      Consensus CDS
      CCDS28048.1
      UniProtKB/Swiss-Prot
      P84091
      UniProtKB/TrEMBL
      Q5FWI9
      Related
      ENSMUSP00000007216.8, OTTMUSP00000031894, ENSMUST00000007216.8, OTTMUST00000064275
      Conserved Domains (1) summary
      cd09251
      Location:168434
      AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      20535480..20544909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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