Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Tlr5 toll-like receptor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289337, updated on 22-Apr-2017
    Official Symbol
    Tlr5provided by RGD
    Official Full Name
    toll-like receptor 5provided by RGD
    Primary source
    RGD:631351
    See related
    Ensembl:ENSRNOG00000022067
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Orthologs
    Location:
    13q26
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (101364784..101385764)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (106294254..106315238)

    Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene sushi domain containing 4 Neighboring gene similar to ubiquitin C Neighboring gene uncharacterized LOC108352585 Neighboring gene uncharacterized LOC102555375

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016
    • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
      Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
      Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystem
      Toll-like receptor signaling pathway

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    interleukin-1 receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MyD88-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of interleukin-8 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytokine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    toll-like receptor 5 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145828.1NP_001139300.1  toll-like receptor 5

      See identical proteins and their annotated locations for NP_001139300.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473985
      UniProtKB/TrEMBL
      G3V6F8
      Related
      ENSRNOP00000004821.3, ENSRNOT00000004821.4
      Conserved Domains (5) summary
      cd00116
      Location:350594
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:302325
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:706856
      TIR; TIR domain
      pfam13855
      Location:326384
      LRR_8; Leucine rich repeat
      cl15307
      Location:592643
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

      Range
      101364784..101385764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769826.2XP_008768048.1  toll-like receptor 5 isoform X2

      See identical proteins and their annotated locations for XP_008768048.1

      UniProtKB/TrEMBL
      C0LP03
      Conserved Domains (5) summary
      cd00116
      Location:338582
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:290313
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:694844
      TIR; TIR domain
      pfam13855
      Location:314372
      LRR_8; Leucine rich repeat
      cl15307
      Location:580631
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    2. XM_017598732.1XP_017454221.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      G3V6F8
      Conserved Domains (5) summary
      cd00116
      Location:350594
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:302325
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:706856
      TIR; TIR domain
      pfam13855
      Location:326384
      LRR_8; Leucine rich repeat
      cl15307
      Location:592643
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    3. XM_006250376.2XP_006250438.1  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006250438.1

      UniProtKB/TrEMBL
      G3V6F8
      Conserved Domains (5) summary
      cd00116
      Location:350594
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:302325
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:706856
      TIR; TIR domain
      pfam13855
      Location:326384
      LRR_8; Leucine rich repeat
      cl15307
      Location:592643
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    4. XM_017598733.1XP_017454222.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      G3V6F8
      Conserved Domains (5) summary
      cd00116
      Location:350594
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:302325
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:706856
      TIR; TIR domain
      pfam13855
      Location:326384
      LRR_8; Leucine rich repeat
      cl15307
      Location:592643
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    5. XM_017598734.1XP_017454223.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      G3V6F8
      Conserved Domains (5) summary
      cd00116
      Location:350594
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:302325
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:706856
      TIR; TIR domain
      pfam13855
      Location:326384
      LRR_8; Leucine rich repeat
      cl15307
      Location:592643
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    Alternate Rn_Celera

    Genomic

    1. AC_000081.1 Alternate Rn_Celera

      Range
      94180743..94184997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center