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    LTN1 listerin E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

    Gene ID: 26046, updated on 5-Nov-2017
    Official Symbol
    LTN1provided by HGNC
    Official Full Name
    listerin E3 ubiquitin protein ligase 1provided by HGNC
    Primary source
    HGNC:HGNC:13082
    See related
    Ensembl:ENSG00000198862 MIM:613083; Vega:OTTHUMG00000078803
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF160; ZNF294; C21orf10; C21orf98
    Summary
    Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]
    Orthologs
    Location:
    21q21.3
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 21 NC_000021.9 (28928144..28992959, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (30300466..30365277, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 7 Neighboring gene THUMP domain containing 1 pseudogene 1 Neighboring gene uncharacterized LOC105372766 Neighboring gene ribosomal protein L23 pseudogene 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ11053, KIAA0714

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protein autoubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    E3 ubiquitin-protein ligase listerin
    Names
    RING-type E3 ubiquitin transferase listerin
    ring finger protein 160
    zinc finger protein 294
    NP_001307695.1
    NP_056380.2
    XP_006724050.1
    XP_016883805.1
    XP_016883806.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320766.1NP_001307695.1  E3 ubiquitin-protein ligase listerin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame exon in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AF260011, AI279340, AL703566, BC029371, BC045726, BU193344, BX282248, BX479990, CN361589, CN361592, CN361594, DB636695, HY001556
      UniProtKB/Swiss-Prot
      O94822
      Conserved Domains (1) summary
      pfam13639
      Location:17451794
      zf-RING_2; Ring finger domain
    2. NM_015565.2NP_056380.2  E3 ubiquitin-protein ligase listerin isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB018257, BC140790, BF059116, DB452437
      Consensus CDS
      CCDS33527.2
      UniProtKB/Swiss-Prot
      O94822
      Related
      ENSP00000478783.1, ENST00000614971.4
      Conserved Domains (1) summary
      pfam13639
      Location:17591808
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p7 Primary Assembly

      Range
      28928144..28992959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028316.1XP_016883805.1  E3 ubiquitin-protein ligase listerin isoform X1

    2. XM_017028317.1XP_016883806.1  E3 ubiquitin-protein ligase listerin isoform X2

    3. XM_006723987.3XP_006724050.1  E3 ubiquitin-protein ligase listerin isoform X3

      Conserved Domains (1) summary
      COG5219
      Location:105308
      COG5219; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

    Alternate CHM1_1.1

    Genomic

    1. NC_018932.2 Alternate CHM1_1.1

      Range
      29862811..29927627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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