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    Gper1 G protein-coupled estrogen receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 76854, updated on 6-Sep-2017
    Official Symbol
    Gper1provided by MGI
    Official Full Name
    G protein-coupled estrogen receptor 1provided by MGI
    Primary source
    MGI:MGI:1924104
    See related
    Ensembl:ENSMUSG00000053647 Vega:OTTMUSG00000021296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gper; Ceprl; FEG-1; Gpr30; CMKRL2; GPCR-Br; 6330420K13Rik
    Orthologs
    Location:
    5; 5 G2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (139422969..139427800)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (139899133..139903754)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110082I17 gene Neighboring gene RIKEN cDNA D830046C22 gene Neighboring gene G protein-coupled receptor 146 Neighboring gene RIKEN cDNA C130050O18 gene Neighboring gene zinc finger, AN1-type domain 2A Neighboring gene RIKEN cDNA 4930500L23 gene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    estrogen receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    mineralocorticoid receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    steroid binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to estradiol stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to estradiol stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to mineralocorticoid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to peptide hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular steroid hormone receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular steroid hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell cycle process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of leukocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vascular smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear fragmentation involved in apoptotic nuclear change ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of G-protein coupled receptor protein signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac vascular smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inositol trisphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neurogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of uterine smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine head ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine membrane ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    keratin filament ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    G-protein coupled estrogen receptor 1
    Names
    G-protein coupled receptor 30
    chemoattractant receptor-like 2
    constitutively expressed peptide-like receptor like
    mER
    membrane estrogen receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029771.3NP_084047.2  G-protein coupled estrogen receptor 1

      See identical proteins and their annotated locations for NP_084047.2

      Status: VALIDATED

      Source sequence(s)
      AK030375, BC138616, CX204119
      Consensus CDS
      CCDS19811.1
      UniProtKB/Swiss-Prot
      Q8BMP4
      Related
      ENSMUSP00000080370.3, OTTMUSP00000023577, ENSMUST00000066211.4, OTTMUST00000050492
      Conserved Domains (1) summary
      cd14989
      Location:60335
      7tmA_GPER1; G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      139422969..139427800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504757.3XP_006504820.1  G-protein coupled estrogen receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006504820.1

      UniProtKB/Swiss-Prot
      Q8BMP4
      Conserved Domains (1) summary
      cd14989
      Location:60335
      7tmA_GPER1; G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
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