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    Inpp5b inositol polyphosphate-5-phosphatase B [ Mus musculus (house mouse) ]

    Gene ID: 16330, updated on 6-Aug-2017
    Official Symbol
    Inpp5bprovided by MGI
    Official Full Name
    inositol polyphosphate-5-phosphatase Bprovided by MGI
    Primary source
    MGI:MGI:103257
    See related
    Ensembl:ENSMUSG00000028894 Vega:OTTMUSG00000009176
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5PTase; INPP5P; AW260155
    Summary
    This gene encodes a member of the inositol polyphosphate-5-phosphatase (INPP5) family. This protein hydrolyzes the 5' phosphate from phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol-1,4,5-trisphosphate, which results in changes to multiple signaling pathways. This protein may be involved in protein trafficking and secretion. Homozygous knockout mice exhibit impaired spermatogenesis and male sterility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
    Orthologs
    Location:
    4 D2.2; 4 57.89 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (124741827..124801511)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (124419122..124478755)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene splicing factor 3a, subunit 3 Neighboring gene microRNA 697 Neighboring gene predicted gene 12915 Neighboring gene predicted gene, 32117 Neighboring gene microRNA 698 Neighboring gene metal response element binding transcription factor 1 Neighboring gene RIKEN cDNA 1110065P20 gene Neighboring gene mannosidase, endo-alpha-like Neighboring gene yrdC domain containing (E.coli)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inositol-1,4,5-trisphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inositol-1,4,5-trisphosphate 5-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    inositol-polyphosphate 5-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    phosphatidylinositol dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    type II inositol 1,4,5-trisphosphate 5-phosphatase
    Names
    inositol polyphosphate-5-phosphatase, 75 kDa
    phosphoinositide 5-phosphatase
    NP_032411.3
    XP_006502867.1
    XP_006502868.1
    XP_006502872.1
    XP_011238752.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008385.4NP_032411.3  type II inositol 1,4,5-trisphosphate 5-phosphatase precursor

      See identical proteins and their annotated locations for NP_032411.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the protein.
      Source sequence(s)
      AK163187, BE988792, BE996479, BG802289, BU610644, BU701664, BU921160, BY778295, CA315937, CA320508, CK390048, DV654857
      Consensus CDS
      CCDS38876.1
      UniProtKB/Swiss-Prot
      Q8K337
      Related
      ENSMUSP00000092375.3, OTTMUSP00000009518, ENSMUST00000094782.9, OTTMUST00000020749
      Conserved Domains (3) summary
      cd09093
      Location:345638
      INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
      cd04380
      Location:772990
      RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
      pfam16776
      Location:6150
      INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain

    RNA

    1. NR_126474.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon as used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA289577, AA881781, AK004722, AK163187, AL606933, BE988792, BU701664, BY778295, CA315937, CA320508
      Related
      ENSMUST00000184454.7, OTTMUST00000020750

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      124741827..124801511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502804.3XP_006502867.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_006502867.1

      Conserved Domains (3) summary
      cd09093
      Location:346639
      INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
      cd04380
      Location:773991
      RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
      pfam16776
      Location:6151
      INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain
    2. XM_011240450.2XP_011238752.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X2

      Conserved Domains (3) summary
      cd09093
      Location:346639
      INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
      cd04380
      Location:773920
      RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
      pfam16776
      Location:6151
      INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain
    3. XM_006502809.3XP_006502872.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X3

      Conserved Domains (2) summary
      pfam16776
      Location:6151
      INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain
      cl00490
      Location:346521
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    4. XM_006502805.2XP_006502868.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_006502868.1

      Conserved Domains (3) summary
      cd09093
      Location:346639
      INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
      cd04380
      Location:773991
      RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
      pfam16776
      Location:6151
      INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain

    RNA

    1. XR_867812.2 RNA Sequence

    2. XR_001784096.1 RNA Sequence

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