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    PCBP3 poly(rC) binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 54039, updated on 4-Feb-2018
    Official Symbol
    PCBP3provided by HGNC
    Official Full Name
    poly(rC) binding protein 3provided by HGNC
    Primary source
    HGNC:HGNC:8651
    See related
    Ensembl:ENSG00000183570 MIM:608502; Vega:OTTHUMG00000090399
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCBP3OT; ALPHA-CP3; PCBP3-OT1
    Summary
    This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
    Expression
    Broad expression in testis (RPKM 8.3), endometrium (RPKM 4.4) and 17 other tissues See more
    Orthologs
    Location:
    21q22.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 21 NC_000021.9 (45849961..45942454)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (47268023..47362368)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985485 Neighboring gene long intergenic non-protein coding RNA 1694 Neighboring gene uncharacterized LOC100129027 Neighboring gene uncharacterized LOC101928796 Neighboring gene uncharacterized LOC105372841

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    NHGRI GWAS Catalog

    Description
    Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of poly(rC) binding protein 3 (PCBP3) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ44028

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    C-rich single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding HDA PubMed 
    RNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    mRNA metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    poly(rC)-binding protein 3
    Names
    PCBP3 overlapping transcript 1
    PCBP3-overlapping transcript
    poly(rC) binding protein 3 overlapping transcript

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130141.1NP_001123613.1  poly(rC)-binding protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001123613.1

      Status: REVIEWED

      Source sequence(s)
      AF176329, BC012061
      Consensus CDS
      CCDS46652.1
      UniProtKB/Swiss-Prot
      P57721
      Related
      ENSP00000383163.1, OTTHUMP00000115468, ENST00000400308.5, OTTHUMT00000206812
      Conserved Domains (2) summary
      cd00105
      Location:269331
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:131195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    2. NM_001348238.1NP_001335167.1  poly(rC)-binding protein 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      UniProtKB/Swiss-Prot
      P57721
      Conserved Domains (2) summary
      cd02396
      Location:131195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:294358
      KH_1; KH domain
    3. NM_001348239.1NP_001335168.1  poly(rC)-binding protein 3 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript.
      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      Conserved Domains (2) summary
      cd02396
      Location:131195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:317381
      KH_1; KH domain
    4. NM_001348240.1NP_001335169.1  poly(rC)-binding protein 3 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL133493, AL592528
      Conserved Domains (2) summary
      cd02396
      Location:131195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:318382
      KH_1; KH domain
    5. NM_001348241.1NP_001335170.1  poly(rC)-binding protein 3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL592528
      Conserved Domains (2) summary
      cd02396
      Location:131195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:306370
      KH_1; KH domain
    6. NM_001348242.1NP_001335171.1  poly(rC)-binding protein 3 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL592528
      UniProtKB/Swiss-Prot
      P57721
      Conserved Domains (2) summary
      cd02396
      Location:99163
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:263327
      KH_1; KH domain
    7. NM_001348243.1NP_001335172.1  poly(rC)-binding protein 3 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL592528
      Conserved Domains (2) summary
      cd02396
      Location:131195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:274338
      KH_1; KH domain
    8. NM_001348244.1NP_001335173.1  poly(rC)-binding protein 3 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AK094301, AL592528, BC012061
      UniProtKB/Swiss-Prot
      P57721
      Conserved Domains (2) summary
      cd02396
      Location:131195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:275339
      KH_1; KH domain
    9. NM_001348245.1NP_001335174.1  poly(rC)-binding protein 3 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL592528
      Conserved Domains (2) summary
      cd02396
      Location:131195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam00013
      Location:297361
      KH_1; KH domain
    10. NM_020528.2NP_065389.2  poly(rC)-binding protein 3 isoform 1

      See identical proteins and their annotated locations for NP_065389.2

      Status: REVIEWED

      Source sequence(s)
      AF176329, BC012061
      Consensus CDS
      CCDS42974.2
      UniProtKB/Swiss-Prot
      P57721
      Related
      ENSP00000383168.1, OTTHUMP00000115464, ENST00000400314.5, OTTHUMT00000206808
      Conserved Domains (2) summary
      cd00105
      Location:295357
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:131195
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    RNA

    1. NR_145492.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL133492, AL592528
    2. NR_145493.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AJ011931, AJ239328, AL592528

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p7 Primary Assembly

      Range
      45849961..45942454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018932.2 Alternate CHM1_1.1

      Range
      46830711..46923863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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