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    Trmt2a TRM2 tRNA methyltransferase 2A [ Mus musculus (house mouse) ]

    Gene ID: 15547, updated on 22-Apr-2017
    Official Symbol
    Trmt2aprovided by MGI
    Official Full Name
    TRM2 tRNA methyltransferase 2Aprovided by MGI
    Primary source
    MGI:MGI:96270
    See related
    Ensembl:ENSMUSG00000022721 Vega:OTTMUSG00000026007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Htf9c
    Orthologs
    Location:
    16 A3; 16 11.31 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (18248858..18254772)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (18248976..18253595)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene zinc finger, DHHC domain containing 8 Neighboring gene RAN binding protein 1 Neighboring gene DGCR8, microprocessor complex subunit Neighboring gene microRNA 1306 Neighboring gene predicted gene, 24572

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    tRNA (uracil-5-)-methyltransferase homolog A
    Names
    TRM2 tRNA methyltransferase 2 homolog A
    hpaII tiny fragments locus 9c protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080999.2NP_001074468.1  tRNA (uracil-5-)-methyltransferase homolog A isoform 2

      See identical proteins and their annotated locations for NP_001074468.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment of the 5' UTR and 5' coding region, and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is the same length as isoform 1.
      Source sequence(s)
      AC084822, AK080170, AK134368
      Consensus CDS
      CCDS37281.1
      UniProtKB/Swiss-Prot
      Q8BNV1
      UniProtKB/TrEMBL
      Q3UYU2
      Related
      ENSMUSP00000111304.1, OTTMUSP00000031834, ENSMUST00000115640.7, OTTMUST00000064177
      Conserved Domains (4) summary
      COG0724
      Location:60201
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      COG2265
      Location:169571
      TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
      cd12439
      Location:58136
      RRM_TRMT2A; RNA recognition motif in tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) and similar proteins
      cl17173
      Location:375578
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001081000.2NP_001074469.1  tRNA (uracil-5-)-methyltransferase homolog A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC084822, AK080170, AK134368, BY090144
      Consensus CDS
      CCDS37282.1
      UniProtKB/Swiss-Prot
      Q8BNV1
      UniProtKB/TrEMBL
      E9PUQ7, Q3UYU2
      Related
      ENSMUSP00000111303.2, OTTMUSP00000032230, ENSMUST00000100099.9, OTTMUST00000064828
      Conserved Domains (4) summary
      COG0724
      Location:60201
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      COG2265
      Location:169571
      TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
      cd12439
      Location:58136
      RRM_TRMT2A; RNA recognition motif in tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) and similar proteins
      cl17173
      Location:375578
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_001195205.1NP_001182134.1  tRNA (uracil-5-)-methyltransferase homolog A isoform 4

      See identical proteins and their annotated locations for NP_001182134.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks a segment of the 5' UTR and 5' coding region, uses an upstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC084822, AK080170, CJ049472
      Consensus CDS
      CCDS57020.1
      UniProtKB/Swiss-Prot
      Q8BNV1
      Related
      ENSMUSP00000121216.1, OTTMUSP00000031833, ENSMUST00000140206.7, OTTMUST00000064176
      Conserved Domains (4) summary
      COG0724
      Location:60201
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      COG2265
      Location:169532
      TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
      cd12439
      Location:58136
      RRM_TRMT2A; RNA recognition motif in tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) and similar proteins
      cl17173
      Location:375539
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      18248858..18254772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316881.1XP_017172370.1  tRNA (uracil-5-)-methyltransferase homolog A isoform X1

      UniProtKB/TrEMBL
      Q05BM5
      Conserved Domains (4) summary
      COG0724
      Location:49190
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      COG2265
      Location:158560
      TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
      cd12439
      Location:47125
      RRM_TRMT2A; RNA recognition motif in tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) and similar proteins
      cl17173
      Location:364567
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_006521805.3XP_006521868.1  tRNA (uracil-5-)-methyltransferase homolog A isoform X2

      See identical proteins and their annotated locations for XP_006521868.1

      Conserved Domains (4) summary
      COG0724
      Location:60201
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      COG2265
      Location:270494
      TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
      cd12439
      Location:58136
      RRM_TRMT2A; RNA recognition motif in tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) and similar proteins
      cl17173
      Location:298501
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    Reference GRCm38.p4 PATCHES

    Genomic

    1. NW_004450262.1 Reference GRCm38.p4 PATCHES

      Range
      23221..29110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 129S6/SvEvTac

    Genomic

    1. NT_187012.1 Reference GRCm38.p4 129S6/SvEvTac

      Range
      57441..63330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_008307.2: Suppressed sequence

      Description
      NM_008307.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which retains an intron.
    Support Center