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    Isl1 ISL1 transcription factor, LIM/homeodomain [ Mus musculus (house mouse) ]

    Gene ID: 16392, updated on 23-Apr-2017
    Official Symbol
    Isl1provided by MGI
    Official Full Name
    ISL1 transcription factor, LIM/homeodomainprovided by MGI
    Primary source
    MGI:MGI:101791
    See related
    Ensembl:ENSMUSG00000042258 Vega:OTTMUSG00000039739
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    13; 13 D2.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (116298257..116309721, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (117088478..117099896, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene Neighboring gene ribosomal protein L34, pseudogene 2 Neighboring gene predicted gene, 29764 Neighboring gene RIKEN cDNA 4930435F18 gene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ligand-dependent nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    atrial septum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cardiac cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac cell fate determination ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle cell myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac right ventricle morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endocardial cushion morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    innervation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesenchymal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural crest cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron fate commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    outflow tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    outflow tract septum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peripheral nervous system neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peripheral nervous system neuron development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pharyngeal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pituitary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of granulocyte colony-stimulating factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of granulocyte macrophage colony-stimulating factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of histone acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-gamma production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-1 alpha production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-1 beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of macrophage colony-stimulating factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of vascular endothelial growth factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of secondary heart field cardioblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    secondary heart field specification ISO
    Inferred from Sequence Orthology
    more info
     
    sensory system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spinal cord motor neuron cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    spinal cord motor neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trigeminal nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular cardiac muscle tissue morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    visceral motor neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    insulin gene enhancer protein ISL-1
    Names
    Islet 1
    Lim-homeodomain protein Islet1
    insulin related protein
    islet-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021459.4NP_067434.3  insulin gene enhancer protein ISL-1

      See identical proteins and their annotated locations for NP_067434.3

      Status: VALIDATED

      Source sequence(s)
      AC170086, AK090263, CF725499
      Consensus CDS
      CCDS26790.1
      UniProtKB/Swiss-Prot
      P61372
      UniProtKB/TrEMBL
      A2RSV5, Q8BTH7
      Related
      ENSMUSP00000044879.6, OTTMUSP00000057705, ENSMUST00000036060.12, OTTMUST00000103329
      Conserved Domains (3) summary
      cd09366
      Location:1771
      LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family
      cd09374
      Location:79133
      LIM2_Isl; The second LIM domain of Isl, a member of LHX protein family
      smart00389
      Location:181237
      HOX; Homeodomain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      116298257..116309721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517533.2XP_006517596.1  insulin gene enhancer protein ISL-1 isoform X1

      See identical proteins and their annotated locations for XP_006517596.1

      UniProtKB/Swiss-Prot
      P61372
      Related
      ENSMUSP00000135567.1, OTTMUSP00000057706, ENSMUST00000176044.2, OTTMUST00000103330
      Conserved Domains (4) summary
      cd09366
      Location:1771
      LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family
      cd09374
      Location:79133
      LIM2_Isl; The second LIM domain of Isl, a member of LHX protein family
      smart00389
      Location:181237
      HOX; Homeodomain
      COG5576
      Location:145268
      COG5576; Homeodomain-containing transcription factor [Transcription]
    2. XM_017315398.1XP_017170887.1  insulin gene enhancer protein ISL-1 isoform X2

      Conserved Domains (1) summary
      smart00389
      Location:3389
      HOX; Homeodomain
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