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    RAB11FIP1 RAB11 family interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 80223, updated on 19-Nov-2017
    Official Symbol
    RAB11FIP1provided by HGNC
    Official Full Name
    RAB11 family interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:30265
    See related
    Ensembl:ENSG00000156675 MIM:608737; Vega:OTTHUMG00000164026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RCP; NOEL1A; rab11-FIP1
    Summary
    This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]
    Expression
    Broad expression in lung (RPKM 41.1), small intestine (RPKM 24.3) and 22 other tissues See more
    Orthologs
    Location:
    8p11.23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (37858947..37899516, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (37716465..37757015, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379381 Neighboring gene adhesion G protein-coupled receptor A2 Neighboring gene BRF2, RNA polymerase III transcription initiation factor subunit Neighboring gene RNA, 7SL, cytoplasmic 709, pseudogene Neighboring gene glutamic-oxaloacetic transaminase 1 like 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of RAB11-FIP1C by shRNA inhibits HIV-1 infectivity in TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The interaction of RAB11-FIP1C with RAB14 is required for incorporation of HIV-1 Env (gp120/gp41) into virions PubMed
    env RAB11-FIP1C is required for HIV-1 Env (gp120/gp41) incorporation into virions, while depletion of RAB11-FIP1C by shRNA diminishes Env incorporation into virions PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 Env relocalizes FIP1C to plasma membrane in a cytoplasmic tail-dependent manner PubMed
    env RAB11-FIP1C is required for HIV-1 Env (gp120/gp41) incorporation into virions, while depletion of RAB11-FIP1C by shRNA diminishes Env incorporation into virions PubMed
    Envelope transmembrane glycoprotein gp41 env Second-site reversion mutation in theHIV-1 gp41 cytoplasmic tail is required to restore HIV-1 Env incorporation in YW795SL gp41 mutant in all cell types PubMed
    env The YW795 motif in the HIV-1 gp41 cytoplasmic tail is required for efficient cell-to-cell spread in nonpermissive cells PubMed
    env The YW795 motif in the HIV-1 gp41 cytoplasmic tail is required for HIV-1 Env-mediated redistribution of RAB11FIP1 and for Env incorporation in to virions PubMed
    env The interaction of RAB11-FIP1C with RAB14 is required for incorporation of HIV-1 Env (gp120/gp41) into virions PubMed
    env RAB11-FIP1C is required for HIV-1 Env (gp120/gp41) incorporation into virions, while depletion of RAB11-FIP1C by shRNA diminishes Env incorporation into virions PubMed

    Go to the HIV-1, Human Interaction Database

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ22524, FLJ22622, MGC78448, DKFZp686E2214

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Rab GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    negative regulation of adiponectin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    rab11 family-interacting protein 1
    Names
    RAB11 coupling protein
    RAB11 family interacting protein 1 (class I)
    Rab effector protein
    Rab-interacting recycling protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002814.2NP_001002814.2  rab11 family-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001002814.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longer transcript and encodes the longer isoform (3).
      Source sequence(s)
      AC130304, AK026275, AY280968, BC077720
      Consensus CDS
      CCDS34882.1
      UniProtKB/Swiss-Prot
      Q6WKZ4
      Related
      ENSP00000331342.4, OTTHUMP00000225616, ENST00000330843.8, OTTHUMT00000376816
      Conserved Domains (2) summary
      cd08682
      Location:20147
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:12261273
      RBD-FIP; FIP domain
    2. NM_025151.4NP_079427.4  rab11 family-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_079427.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 3. It encodes isoform 1, which is shorter than isoform 3.
      Source sequence(s)
      AC130304, AK026275, BC077720
      Consensus CDS
      CCDS34881.1
      UniProtKB/Swiss-Prot
      Q6WKZ4
      Related
      ENSP00000287263.4, OTTHUMP00000225615, ENST00000287263.8, OTTHUMT00000376815
      Conserved Domains (2) summary
      cd08682
      Location:20147
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:592639
      RBD-FIP; FIP domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      37858947..37899516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013869.1XP_016869358.1  rab11 family-interacting protein 1 isoform X1

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      37917911..37958467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001002233.1: Suppressed sequence

      Description
      NM_001002233.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support an internal transcription initiation site.
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