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    GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 23062, updated on 12-Mar-2017
    Official Symbol
    GGA2provided by HGNC
    Official Full Name
    golgi associated, gamma adaptin ear containing, ARF binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:16064
    See related
    Ensembl:ENSG00000103365 MIM:606005; Vega:OTTHUMG00000096957
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VEAR
    Summary
    This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    16p12.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (23463542..23510494, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (23474863..23521815, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene sodium channel epithelial 1 beta subunit Neighboring gene component of oligomeric golgi complex 7 Neighboring gene RNA, 7SK small nuclear pseudogene 23 Neighboring gene cyclin Y like 1 pseudogene Neighboring gene glutamyl-tRNA synthetase 2, mitochondrial Neighboring gene SUB1 homolog, transcriptional regulator pseudogene 4 Neighboring gene ubiquitin family domain containing 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Genome-wide shRNA screening identifies GGA2, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
    Pr55(Gag) gag siRNA-mediated depletion of GGA2 leads to a significant increase in particle release in an HIV-1 Gag late domain-dependent manner, while GGA2 overexpression severely reduces virus particle production by impairing Gag trafficking to the membrane PubMed
    Vpr vpr Expression of a patient-derived HIV-1 Vpr protein reveals a significant reduction in Vpr nuclear import. Vpr F72L mutation is responsible for this decreased Vpr nuclear import and the F72L mutant is co-localized with gamma-adaptin in the Golgi apparatus PubMed

    Go to the HIV-1, Human Interaction Database

    • Amyloid fiber formation, organism-specific biosystem (from REACTOME)
      Amyloid fiber formation, organism-specific biosystemAmyloid is a term used to describe deposits of fibrillar proteins, typically extracellular. The abnormal accumulation of amyloid, amyloidosis, is a term associated with tissue damage caused by amyloi...
    • Lysosome, organism-specific biosystem (from KEGG)
      Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • Lysosome, conserved biosystem (from KEGG)
      Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • TBC/RABGAPs, organism-specific biosystem (from REACTOME)
      TBC/RABGAPs, organism-specific biosystemRab GTPases are peripheral membrane proteins involved in membrane trafficking. Often through their indirect interactions with coat components, motors, tethering factors and SNAREs, the Rab GTPases se...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ20966, KIAA1080

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ADP-ribosylation factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    intracellular protein transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    membrane organization TAS
    Traceable Author Statement
    more info
     
    vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome membrane TAS
    Traceable Author Statement
    more info
     
    endosome membrane TAS
    Traceable Author Statement
    more info
     
    trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ADP-ribosylation factor-binding protein GGA2
    Names
    VHS domain and ear domain of gamma-adaptin
    VHS domain and ear domain-containing protein
    gamma-adaptin-related protein 2
    golgi-localized, gamma ear-containing, ARF-binding protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015044.4NP_055859.1  ADP-ribosylation factor-binding protein GGA2

      See identical proteins and their annotated locations for NP_055859.1

      Status: REVIEWED

      Source sequence(s)
      AC008915, AF165531, DA439738
      Consensus CDS
      CCDS10611.1
      UniProtKB/Swiss-Prot
      Q9UJY4
      Related
      ENSP00000311962, OTTHUMP00000122425, ENST00000309859, OTTHUMT00000214019
      Conserved Domains (4) summary
      smart00809
      Location:491605
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:25163
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      cd14239
      Location:227315
      GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      cl21478
      Location:168240
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

      Range
      23463542..23510494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023075.1XP_016878564.1  ADP-ribosylation factor-binding protein GGA2 isoform X2

    2. XM_017023074.1XP_016878563.1  ADP-ribosylation factor-binding protein GGA2 isoform X1

      Conserved Domains (4) summary
      smart00809
      Location:454568
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:1126
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      cd14239
      Location:190278
      GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      cl21478
      Location:131203
      ATP-synt_B; ATP synthase B/B' CF(0)

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      24486438..24533673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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