Cdc42bpg CDC42 binding protein kinase gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc42bpgprovided by MGI
Official Full Name: CDC42 binding protein kinase gammaprovided by MGI
Primary source: MGI:MGI:2652845
See related: Ensembl:ENSMUSG00000024769 AllianceGenome:MGI:2652845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MRCKgamma
Summary: Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in actomyosin structure organization and peptidyl-threonine phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cell leading edge; centriolar satellite; and cytosol. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human CDC42BPG (CDC42 binding protein kinase gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 55.3), colon adult (RPKM 31.8) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.43 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6356465..6375682)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6306253..6325653)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MRCKalpha Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model.
Title: MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model.
MRCKgamma can modulate maturation of dendritic spines in cultured cortical neurons, and it is localized specifically to parallel fiber/Purkinje cell synapses in vivo.
Title: Proteomic studies of a single CNS synapse type: the parallel fiber/purkinje cell synapse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW107720 (e-PCR)
- UniSTS:209415

stSG635729 (e-PCR)
- UniSTS:460899

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-threonine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase MRCK gamma

Names: CDC42 binding protein kinase gamma (DMPK-like); DMPK-like gamma; MRCK gamma; myotonic dystrophy kinase-related CDC42-binding kinase gamma; myotonic dystrophy protein kinase-like alpha; myotonic dystrophy protein kinase-like gamma

NP_001028514.1

EC 2.7.11.1

XP_036017481.1

EC 2.7.11.1

XP_036017482.1

EC 2.7.11.1

XP_036017483.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033342.1 → NP_001028514.1 serine/threonine-protein kinase MRCK gamma

See identical proteins and their annotated locations for NP_001028514.1

Status: VALIDATED

Source sequence(s)

AC127556

Consensus CDS

CCDS50365.1

UniProtKB/Swiss-Prot

Q80UW5

Related

ENSMUSP00000025681.8, ENSMUST00000025681.8

Conserved Domains (7) summary

pfam08826
Location:743 → 798

DMPK_coil; DMPK coiled coil domain like

smart00220
Location:71 → 337

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01243
Location:937 → 1069

PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain

cd05597
Location:69 → 399

STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases

pfam00130
Location:878 → 926

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam00780
Location:1096 → 1359

CNH; CNH domain

pfam09728
Location:452 → 774

Taxilin; Myosin-like coiled-coil protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

6356465..6375682

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161588.1 → XP_036017481.1 serine/threonine-protein kinase MRCK gamma isoform X1

Conserved Domains (5) summary

cd01243
Location:937 → 1069

PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain

cd05597
Location:69 → 399

STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases

TIGR02168
Location:444 → 802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00780
Location:1096 → 1359

CNH; CNH domain

cd20866
Location:878 → 929

C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins
XM_036161589.1 → XP_036017482.1 serine/threonine-protein kinase MRCK gamma isoform X2

Conserved Domains (5) summary

cd01243
Location:936 → 1068

PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain

cd05597
Location:69 → 399

STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases

TIGR02168
Location:444 → 802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00780
Location:1095 → 1358

CNH; CNH domain

cd20866
Location:877 → 928

C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins
XM_036161590.1 → XP_036017483.1 serine/threonine-protein kinase MRCK gamma isoform X3

Conserved Domains (4) summary

cd01243
Location:937 → 1069

PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain

cd05597
Location:69 → 399

STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases

TIGR02168
Location:444 → 802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd20866
Location:878 → 929

C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins