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    ATRN attractin [ Homo sapiens (human) ]

    Gene ID: 8455, updated on 22-Apr-2017
    Official Symbol
    ATRNprovided by HGNC
    Official Full Name
    attractinprovided by HGNC
    Primary source
    HGNC:HGNC:885
    See related
    Ensembl:ENSG00000088812 MIM:603130; Vega:OTTHUMG00000031746
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGCA; DPPT-L
    Summary
    This gene encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines. [provided by RefSeq, Apr 2016]
    Orthologs
    Location:
    20p13
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (3471018..3651122)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3451665..3631769)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene chromosome 20 open reading frame 194 Neighboring gene ubiquitin conjugating enzyme E2 V1 pseudogene 1 Neighboring gene uncharacterized LOC105372508 Neighboring gene uncharacterized LOC105372509 Neighboring gene splicing factor 3a, subunit 3 pseudogene 1 Neighboring gene GDNF family receptor alpha 4 Neighboring gene ADAM metallopeptidase domain 33

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0548, MGC126754

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cerebellum development IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    myelination IEA
    Inferred from Electronic Annotation
    more info
     
    pigmentation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    attractin
    Names
    attractin-2
    mahogany homolog
    mahogany protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029406.1 RefSeqGene

      Range
      5001..185105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001207047.2NP_001193976.1  attractin isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of the first exon and differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (4) has distinct N- and C-termini compared to isoform 1. Unlike isoform 1, which is membrane-bound, isoform 4 is secreted.
      Source sequence(s)
      AK293010, AK302730, BC101705, DA368237
      UniProtKB/Swiss-Prot
      O75882
      UniProtKB/TrEMBL
      B4DZ36
      Conserved Domains (7) summary
      cd03597
      Location:672804
      CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
      cd00041
      Location:23131
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:946991
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:385434
      Kelch; KELCH repeat [structural motif]
      pfam01437
      Location:816867
      PSI; Plexin repeat
      pfam13415
      Location:234284
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:274312
      Kelch_5; Kelch motif
    2. NM_001323332.1NP_001310261.1  attractin isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AK293010, AL132773
      UniProtKB/Swiss-Prot
      O75882
      Conserved Domains (7) summary
      cd03597
      Location:788920
      CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
      cd00041
      Location:132247
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:10621107
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:501550
      Kelch; KELCH repeat [structural motif]
      pfam01437
      Location:932983
      PSI; Plexin repeat
      pfam13415
      Location:350400
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:392428
      Kelch_5; Kelch motif
    3. NM_139321.2NP_647537.1  attractin isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_647537.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1), which is contained in the membrane.
      Source sequence(s)
      AB011120, AL132773, BC101705, BE326239, DB240822, EC440053
      Consensus CDS
      CCDS13053.1
      UniProtKB/Swiss-Prot
      O75882
      Related
      ENSP00000262919.5, OTTHUMP00000030103, ENST00000262919.9, OTTHUMT00000077740
      Conserved Domains (7) summary
      cd03597
      Location:788920
      CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
      cd00041
      Location:132247
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:10621107
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:501550
      Kelch; KELCH repeat [structural motif]
      pfam01437
      Location:932983
      PSI; Plexin repeat
      pfam13415
      Location:350400
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:390428
      Kelch_5; Kelch motif
    4. NM_139322.3NP_647538.1  attractin isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_647538.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1, resulting in an isoform (2) with a distinct C-terminus compared to isoform 1. Unlike isoform 1, which is membrane-bound, isoform 2 is secreted.
      Source sequence(s)
      AK293010, AK302730, BC101705, EC440053
      Consensus CDS
      CCDS13054.1
      UniProtKB/Swiss-Prot
      O75882
      UniProtKB/TrEMBL
      B4DZ36
      Related
      ENSP00000416587.2, OTTHUMP00000030102, ENST00000446916.2, OTTHUMT00000077739
      Conserved Domains (7) summary
      cd03597
      Location:788920
      CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
      cd00041
      Location:132247
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:10621107
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:501550
      Kelch; KELCH repeat [structural motif]
      pfam01437
      Location:932983
      PSI; Plexin repeat
      pfam13415
      Location:350400
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:392428
      Kelch_5; Kelch motif

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      3471018..3651122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      3451974..3632086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_012070.2: Suppressed sequence

      Description
      NM_012070.2: This RefSeq was permanently suppressed because it was based on a sequence representing a cloning artifact.
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